Kahn Laboratory

Our Major Research Interests

  • Molecular mechanisms of insulin resistance.
  • Molecular pathogenesis of type 2 diabetes.
  • Pathogenesis of obesity.
  • Insulin action, glucose transport, leptin action, metabolism.
  • The adipocyte as an endocrine organ.

Recent Work

  • Discovered new signaling pathway involved in leptin action - AMP activated protein kinase.
  • Discovered importance of the Glut4 glucose transporter in adipocytes in whole body insulin action.
  • Investigating the role of protein tyrosine phosphatase 1B and other phosphatases in insulin action and body weight regulation.
  • Discovered that PTP1B regulates leptin signaling by dephosphorylating Jak 2.

For a complete listing of Dr. Kahn's publications, click here.