Our Major Research Interests
Molecular mechanisms of insulin resistance.
Molecular pathogenesis of type 2 diabetes.
Pathogenesis of obesity.
Insulin action, glucose transport, leptin action, metabolism.
The adipocyte as an endocrine organ.
Discovered new signaling pathway involved in leptin action - AMP
activated protein kinase.
Discovered importance of the Glut4 glucose transporter in adipocytes in
whole body insulin action.
Investigating the role of protein tyrosine phosphatase 1B and other
phosphatases in insulin action and body weight regulation.
Discovered that PTP1B regulates leptin signaling by dephosphorylating
For a complete listing of Dr. Kahn's publications,