Simon C. Body, MD ChB MPH FAHA

About Dr. Simon Body

Dr. Simon Body is Associate Professor of Anesthesiology and Vice Chair of Research in the Department of Anesthesia, Critical Care and Pain Medicine at BIDMC. Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s Hospital, Dr. Body joined BIDMC in 2018. His clinical expertise is in adult cardiac anesthesia.

He commenced his research path in 2001, obtaining Foundation funding from the Society of Cardiovascular Anesthesiologists and Foundation for Anesthesia Education and Research. He then completed K23 training in cardiovascular genetics and obtained NIH R01 funding to investigate the causes of perioperative atrial fibrillation, then bicuspid aortic valve disease.

Dr. Body’s principal research interests are the effects of genetic inputs on the occurrence of adverse outcomes after cardiac surgery and the genetic causes of bicuspid aortic valve disease and its consequences - calcific aortic valve disease and aortic aneurysm. Dr. Body has extensive experience mentoring clinical and research residents, fellows and staff.

Selected Publications

Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J,Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 Jul 24;138(4):377-393. doi:10.1161/CIRCULATIONAHA.117.032291. PubMed PMID: 29588317; PubMed Central PMCID:PMC6160370.

Gharibeh L, Komati H, Bossé Y, Boodhwani M, Heydarpour M, Fortier M,Hassanzadeh R, Ngu J, Mathieu P, Body S, Nemer M; Bicuspid Aortic Valve Consortium. GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve. Circulation. 2018 Sep4;138(10):1025-1038. doi: 10.1161/CIRCULATIONAHA.117.029506. PubMed PMID:29567669; PubMed Central PMCID: PMC6151169.

Helgadottir A, Thorleifsson G, Gretarsdottir S, Stefansson OA, Tragante V,Thorolfsdottir RB, Jonsdottir I, Bjornsson T, Steinthorsdottir V, Verweij N,Nielsen JB, Zhou W, Folkersen L, Martinsson A, Heydarpour M, Prakash S, Oskarsson G, Gudbjartsson T, Geirsson A, Olafsson I, Sigurdsson EL, Almgren P, Melander O, Franco-Cereceda A, Hamsten A, Fritsche L, Lin M, Yang B, Hornsby W, Guo D,Brummett CM, Abecasis G, Mathis M, Milewicz D, Body SC, Eriksson P, Willer CJ,Hveem K, Newton-Cheh C, Smith JG, Danielsen R, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K. Genome-wide analysis yields new loci associating with aortic valve stenosis. Nat Commun. 2018 Mar 7;9(1):987. doi:10.1038/s41467-018-03252-6. PubMed PMID: 29511194; PubMed Central PMCID:PMC5840367.

Kaneko T, Shekar P, Ivkovic V, Longford NT, Huang CC, Sigurdsson MI, Neely RC,Yammine M, Ejiofor JI, Montiero Vieira V, Shahram JT, Habchi KM, Malzberg GW,Martin PS, Bloom J, Isselbacher EM, Muehlschlegel JD; Bicuspid Aortic Valve Consortium (BAVCon), Sundt TM 3rd, Body SC. Should the dilated ascending aorta berepaired at the time of bicuspid aortic valve replacement? Eur J CardiothoracSurg. 2018 Mar 1;53(3):560-568. doi: 10.1093/ejcts/ezx387. PubMed PMID: 29149323;PubMed Central PMCID: PMC6018902. 5: Yassine NM, Shahram JT, Body SC. Pathogenic Mechanisms of Bicuspid AorticValve Aortopathy. Front Physiol. 2017 Sep 25;8:687. doi:10.3389/fphys.2017.00687. eCollection 2017. Review. PubMed PMID: 28993736; PubMed Central PMCID: PMC5622294.