Dr. Yunping Li is an Assistant Professor of Anaesthesia at Harvard Medical School and attending anesthesiologist in the Department of Anesthesia, Critical Care and Pain Medicine, focusing in Obstetric Anesthesia and anesthesia for gynecological surgery. Dr. Li joined the Department in 2000 after completing anesthesia residency at BIDMC.

As a clinical investigator, Dr. Yunping was successful in obtaining funding both from a NIH T32 training grant, and a FAER Mentored Research Training Grant through American Society of Anesthesiology. She was then awarded the Milton Fund through Harvard Medical School. Her interests span both signal transduction in uterine smooth muscle and obstetric anesthesia clinical research.  

In several recent publications, Dr. Li has shown that focal adhesion - Src signaling is required for myometrial activation and contractile phenotype switch before labor onset. In addition to her basic science research, Dr. Li is also pursuing clinical research. She and her colleagues have demonstrated that epidural analgesia will not prolong the second stage of labor, specifically the epidural uses lower concentration of local anesthetics. This contrasts to many obstetricians’ fear that epidural anesthesia lengthens the duration of labor. Her current research focuses on gastric emptying during labor and optimal post cesarean delivery pain control. 

Selected Publications:

  1. Li Y, *Reznichenko M, Tribe RM, Hess PE, Taggart M, Kim HR, DeGnore JP, Gangopadhyay S and Morgan KG. Stretch Activates Human Myometrium via ERK, Caldesmon and Focal Adhesion Signaling. PLoS ONE 2009; 4(10): e7489. doi:10.1371/journal.pone.0007489.
  2.    Hu LQ, Flood P, Li Y, Tao W, Zhao P, Xia Y, Pian-Smith MC, Stellaccio FS, Ouanes JP, Hu F and Wong CA. No Pain Labor & Delivery: A Global Health Initiative’s Impact on Clinical Outcomes in China. Anesthesia Analgesia 2016; 122(6): 1931-8.
  3.    Shen X, Li Y, Xu S, Wang N, Fan S, Qin X, Zhou C and Hess PE. Epidural analgesia during the second stage of labor: a randomized controlled trial. Obstet Gynecol 2017; 130:1097-103 (PMID:29016499).
  4.    Ciampa E, Li Y, Dillon S, Lecarpentier E, Sorabella L, Libermann TA, Karumanchi A and Hess P. Cerebrospinal fluid protein changes in preeclampsia. Hypertension. 2018;72(1):219-226 (with Editorial Commentary) (PMID: 29844151).
  5. Li Y, Dalela S, Kraemer J, Kung A, Vasudevan A and Hess PE. Alpha-2 Adrenergic Activation Improves Continuous Labor Epidural Pain Relief. J Anesth Perioper Med, Special issue on Obstetric Anesthesia. In Press.