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Dr. Subramaniam’s research program is focused on perioperative outcomes and includes the following areas of interest:
Postoperative Neurocognitive Function. Key projects in this area investigate the use of IV Acetaminophen for prevention of postoperative delirium in elderly patients, the association between intraoperative hypotension and postoperative delirium and the effectiveness of pecto-intercostal fascial plane block (PIFB) with bupivacaine as a therapy for postoperative analgesia after cardiac surgery.
Perioperative Hemodynamics. His projects are aimed at: 1) Identifying dynamic biomarkers of intraoperative instability, 2) Identifying a blood pressure complexity index that can predict surgical risk, 3) Identifying the association between perioperative baseline blood pressure, intraoperativehypotension (IOH) and postoperative adverse outcomes in patients undergoing vascular surgery and 4) Developing Light EnhancedTransesophageal Echocardiography.
Wellness Resilience. Over the past few years, Dr. Subramaniam began investigating the effect of meditation in the perioperative setting and wellness resilience.
Sadhguru joins a panel with Anaesthesia professors at HMS
Guided meditation with Sadhguru
About Bala Subramaniam
Dr. Subramaniam received his medical degree from Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER, Pondicherry, India) and completed his residency in anesthesiology at All India Institute of Medical Sciences, New Delhi, India. He received his postdoctoral training in Anesthesia at Beth Israel Medical Center, Harvard Medical School in Boston. Dr. Subramaniam completed fellowships in Cardiac Anesthesia and Transesophageal Echocardiography, both Beth Israel Medical Center in Boston. He also obtained a MPH from Harvard School of Public Health. Since 2014 he has served as the Director of the Center for Anesthesia Research Excellence (CARE). In 2019 he was appointed as the first incumbent of the Ellison "Jeep" Pierce Chair of Anesthesia. Dr. Subramaniam’s research program is funded by grants from the National Institutes of Health as well as the pharmaceutical industry.
Subramaniam B, Shankar P, Shaefi S, Mueller A, O’Gara B, Banner-Goodspeed V, Gasangwa D, Patxot M, Packiasabapathy S, Mathur P, Eikermann M, Talmor D, Marcantonio ER. Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. JAMA. 2019 Feb 19;321(7):686-696. doi: 10.1001/jama.2019.0234
Subramaniam B, Pawar DK, Kashyap L. Pre-emptive analgesia with epidural morphine or morphine and bupivacaine. Anaesth Intensive Care. 2000; 28(4):392-8.
Fernandez-Bustamante A, Frendl G, Sprung J, Kor DJ, Subramaniam B, Ruiz RM, Lee JW, Henderson W, Moss A, Mehdiratta N, Colwell MM, Bartels K, Kolodzie K, Giquel J, Vidal Melo MF. The Perioperative Research Network (PRN) investigators. Multicenter prospective evaluation of postoperative pulmonary complications in non-cardiothoracic surgical patients with severe systemic disease. JAMA Surgery 2017 Feb: 152 (2): 157-166. PMID 27829093
Subramaniam B, Panzica P, Novack V, Mahmood F, Matyal R, Sundar E, *Mitchell J, *Bose R, Pomposelli F, Talmor D. Continuous insulin infusion prevents perioperative myocardial ischemia in patients undergoing non cardiac surgery. A randomized controlled trial. Anesthesiology. 2009; 110: 1-10. [Accompanied by editorial; featured in ASA/Anesthesiology press release and numerous other professional news websites; selected for Faculty of 1000 Medicine]
Ng PY, Ng AK, Subramaniam B, Burns SM, Herisson F, Timm FP, Med C, Rudolph MI, Med C, Scheffenbichler F, Med C, Friedrich S, Med C, Houle TT, Bhatt DL, Eikermann M. Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemic Stroke. JAMA. 2018 Feb 6;319(5):452-462. doi: 10.1001/jama.2017.21899.
Henriques TS, Costa MD, Mathur P, Mathur P, Davis RB, Mittleman MA, Khabbaz KR, Goldberger AL, Subramaniam B. Complexity of preoperative blood pressure dynamics: possible utility in cardiac surgical risk assessment. J Clin Monit Comput. 2019 Feb;33(1):31-38. doi: 10.1007/s10877-018-0133-4. Epub 2018 Mar 21.
Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. A metaanalysis. Anesth Analg. 2004; 99(2):482-495.
Rangasamy V, Thampi Susheela A, Mueller A , Chang T, Sadhasivam S, Subramaniam, B. The effect of a one-time 15-minute guided meditation (Isha Kriya) on stress and mood disturbances among operating room professionals: a prospective interventional pilot study [version 1; peer review: awaiting peer review]. F1000Research 2019, 8:335 (https://doi.org/10.12688/f1000research.18446.1)