Sidney Levitsky, MD
Cheever Professor of Surgery, Harvard Medical School
The primary focus of the laboratory is to elucidate the
mechanisms and subcellular localization of biochemical and molecular events
contributing to myocardial cell death. In particular, we are interested in the
discriminant and/or coordinate contribution of necrosis and apoptosis to
myocardial cell death in the mature and aged male and female, with particular
emphasis on the development of novel and specific cardioprotective protocols.
Study designs utilize models of stunning and ischemia/reperfusion injury in the
isolated Langendorff perfused and the in situ blood perfused heart to determine
the relative contribution of these pathways in the aged as compared to the mature male and female cardiac
Friehs I, Cowan DB, Choi Y-C, Black KM, Barnett R, Bhasin
MK, Daly C, Dillon SJ, Libermann TA, McGowan FX, del Nido PJ, Levitsky S,
McCully JD. Pressure-overload hypertrophy of the developing heart reveals
activation of divergent gene and protein pathways in the left and right
ventricular myocardium. Am J Physiol Heart Circ Physiol 2013;304:H697-708.
Masuzawa A, Black KM, Pacak CA, Ericsson M, Barnett RJ,
Drumm C, Seth P, Bloch DB, Levitsky S, Cowan DB, McCully JD. Transplantation of
autologously-derived mitochondria protects the heart from ischemia-reperfusion
injury. Am J Phys Heart Circ Physiol 2013;304:H966.
Levitsky S, McCully JD. Myocardial Protection. Chapter 66.
In: Sellke FW, Swanson S, del Nido P. Eds. Sabiston & Spencer Surgery of
the Chest, 8th Edition. Philadelphia, PA. 2013
Levitsky S, Chitwood WR, Orringer MB, Mack MJ: Education
above and beyond: Innovative STS educational initiatives. Ann Thorac Surg
Preble JM, Kondo H, Levitsky S, McCully JD: Quality control
parameters for mitochondria transplant in cardiac tissue. JSM Biochemistry and
Molecular Biology; in press.