Preventing Cardiotoxicity in Cancer Survivors

Many highly effective cancer treatments can damage the heart. BIDMC's Cardio-Oncology research program is working to understand the roots of cardiotoxicity with the goal of developing cardioprotective  therapies for a rapidly growing population of cancer survivors.


Aarti H. Asnani, MD, is an attending cardiologist in the CVI's Cardio-Oncology Program and a basic and translational researcher in this field. The main focus of Dr. Asnani’s lab is to identify new mechanisms of cardiovascular toxicity associated with commonly used cancer treatments. Zebrafish and mouse models of cardiotoxicity are used to define candidate pathways involved in the pathogenesis of cardiotoxicity, with the goal of developing new cardioprotective therapies that target these mechanisms in patients.

Ongoing projects in the Asnani lab focus on the following areas:

  1. Cytochrome P450 family 1 enzymes in doxorubicin heart toxicity
  2. Redox biology and characterization of mitochondrial mass and function in doxorubicin heart toxicity
  3. Discovery of new metabolite and protein markers of toxicity in patients treated with cardiotoxic chemotherapy

  4. Development of new animal models to study the tissue-specific effects of cancer treatments

 

See Dr. Asnani’s Harvard Catalyst Profile

_____________________________________________________________________________

Cardiac Toxicity of Cancer Chemotherapy

With the aging of the population, the number of patients diagnosed with cancer has grown significantly over the past few decades. In parallel, survival rates have improved due to increased efficacy and tolerability of cancer treatments. As a result, the acute and long-term toxicities of cancer therapies have become increasingly prominent as contributors to morbidity and mortality in cancer survivors. Read more in this article by Dr. Asnani in US Cardiology Review.

 

 
Asnani Lab Members

Anita Vohra, BS, Research assistant

Cole Turissini, Summer student

Shu Yang, MD, Resident in Internal Medicine, BIDMC

Anuradha Godishala, MD, Fellow in Cardiovascular Medicine, BIDMC