Omega-3 Fatty Acids for Adolescents & Young
Adults with New Changes in Mental Health
Principal Investigator: Larry Seidman, Ph.D.
The central goal of this study is to see if Omega-3 fatty acids (also known
as “fish oil”) improve symptoms and functional outcomes in young adults
with new changes in thinking, feeling or functioning.
What will happen during the study?
Eligible participants will participate in the NAPLS Study baseline
assessments and if eligible, be randomized to six months of Omega-3 or
placebo, with monthly monitoring. Monthly assessments include personal
interviews to discuss your history and possible changes in thinking,
feeling and behavior. Symptoms and side effects will also be monitored, as
well as vital signs, heart rate, weight and waist measurements. In
addition, there will also be a blood draw at three points during the six
month treatment phase to see how the Omega-3 or placebo is working in your
body. At the six month mark, there will be cognitive testing to assess
things like attention and memory, an MRI scan and an EEG of your brain
activity. Participants can also receive up to six months of case management
As a participant, you would be asked to:
Sign a consent form indicating your agreement to participate.
If under age 18, have a parent sign a consent form indicating
his/her agreement for you to participate.
Participate in monthly visits for six months, as well as one follow
up visit after 12 months.
Who can participate?
Individuals between the ages of 12-35 with some of the following
difficulties that have begun or worsened in the past year:
Worrisome drop in grades or work performance
Having trouble thinking clearly, focusing or concentrating
Suspiciousness or uneasiness with others
Decline in self-care or personal-hygiene
Withdrawal from friends or family – spending a lot of time alone
Increased sensitivity to sights or sounds, or mistaking noise for
voices or messages
Having strange feelings or no feelings at all
Feeling like your mind is playing tricks on you
The NAPLS Study takes place at the Commonwealth Research Center of
BIDMC located at the Massachusetts Mental Health Center. Individuals
who complete all parts of the study will be compensated $1025 for their
For more information, please contact:
Corin Pilo at (617) 754-1224
or by email at email@example.com
Chelsea Wakeham at (617) 754-1237
or by email at
To view the brochure please click on the link:
NAPLS Omega-3 brochure