Center for Advanced Orthopaedic Studies (CAOS)


The Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center presently has five full-time principal investigators and additional clinician-scientists who collaborate with laboratory-based investigators. Collectively, the laboratory accommodates approximately 50 researchers, including post-doctoral and research fellows, undergraduate and graduate students.

Meet our Investigators

Bouxsein Lab  Nazarian Lab

Our Expertise

  • Animal models of musculoskeletal disease
  • Cell and molecular biology
  • Fracture risk prediction
  • Mechanical testing
  • Non-invasive assessment of musculoskeletal tissues by micro-computed tomography and related techniques

These techniques are applied to several research areas, including:

  • Bone biomechanics
  • Bone biology
  • Spine biomechanics
  • Gene therapy of arthritis and other joint diseases
  • Regeneration and repair of bone and cartilage
  • Skeletal fragility as a result of osteoporosis and osteolytic tumors
  • Sports medicine and shoulder biomechanics

We intend to build upon these strengths and develop a fully integrated, multi-disciplinary center with research spanning from basic, bench-top studies to clinical trials.

Our Research Facilities

  • General purpose laboratory and preparatory room
  • Micro-computed tomography laboratory
  • Mechanical testing laboratory
  • Cell and molecular biology laboratories
  • An adjacent BIDMC facility for housing small animals greatly facilitates animal studies


For more information, please contact:

Center for Advanced Orthopaedic Studies
Beth Israel Deaconess Medical Center
330 Brookline Ave., RN 115
Boston, MA 02215
Phone; 617-667-2940
Fax: 617-667-7175