OB/GYN Research Publications

Dodge LE, Carterson AJ, Hacker MR, Golen TH, Pratt SD, Sudhof L, Collier AY, Astatke R, Uhl L. Antepartum fibrinogen concentration as a predictor of bleeding complications. Journal of Maternal-Fetal and Neonatal Medicine, 2021;34(21):3586-3590.

Li Y, Ciampa EJ, Zucco L, Levy N, Colella M, Golen T, Shainker SA, Lunderberg JM, Ramachandran SK, Hess PE. Adaptation of an obstetric anesthesia service for the severe acute respiratory syndrome coronavirus-2 pandemic: Description of checklists, workflows, and development tools. Anesthesia & Analgesia, 2021;132(1):31-37. PMCID: PMC7571613

Schaefer KM, Modest AM, Hacker MR, Chie L, Connor Y, Golen T, Molina RL. Language preference and risk of primary cesarean delivery: A retrospective cohort study. Maternal and Child Health Journal, 2021;25(7):1110-1117.

Zucco L, Levy N, Li Y, Golen T, Shainker SA, Hess PE, Ramachandran SK. Rapid cycle implementation and retrospective evaluation of a SARS-CoV-2 checklist in labor and delivery. BMC Health Services Research, 2021;21(1):775. PMCID: PMC8342983

Edmonds JK, Woodbury SR, Lipsitz SR, Weiseth A, Farrell ME, Shah NT, Greene N, Gregory KD. Comparing methods of identifying outlying nurses in audits of low-risk cesarean delivery rates. Journal of Nursing Care Quality, 2022;37(2):149-154.

Dodge LE, Ricardo A, Dutton C, Hacker MR. The influence of advertising policy on information available online for abortion self-referral. Contraception, 2022;S0010-7824(22)00154-8. Epub ahead of print.

Dodge LE, Nippita S, Hacker MR, Intondi E, Ozcelik G, Paul ME. Long-term effects of teamwork training on communication and teamwork climate in ambulatory reproductive healthcare. Journal of Healthcare Risk Management, 2021;40(4):8-15.

Murtha T, Clark K, Hall C, Lee Basgall W, Poyer A, McKenna MJ, Dodge LE. Essential services? Operating status of crisis pregnancy centres in the United States during the COVID-19 pandemic. BMJ Sexual & Reproductive Health, 2021;47(4):304-305.

Winkelman WD, Modest AM, Richardson ML. The surgical approach to abdominal sacrocolpopexy and concurrent hysterectomy: Trends over the past decade. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(1):e196-e201.

Wang R, Hacker MR, Richardson M. Cost-effectiveness of surgical treatment pathways for prolapse. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(2):e408-e413. PMCID: PMC8579510

Winkelman WD, Macharia A, Bharadwa S, Bharadwaj M, Hacker MR, Rosenblatt PL. Composite outcomes following posterior colporrhaphy with and without biologic graft augmentation. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(2):e408-e413. PMCID: PMC8903065

Winkelman WD, Jaresova A, Modest AM, Richardson ML. Postoperative admission, readmission and complications for patients age 60 and older who are undergoing an isolated sling procedure for stress incontinence: A database study. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(6):e542-e548.

Wang R, Tulikangas P, Hacker MR. Variations in volume and costs of inpatient admissions for female pelvic reconstructive procedures across the U.S. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(1):e177-e179. PMCID: PMC7770017

Armstrong KL, Modest AM, Rosenblatt PL. Laparoscopic cerclage sacrohysteropexy: Comparing a novel technique for sacrohysteropexy to traditional supracervical hysterectomy and sacrocervicopexy. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(2):e315-e320.

Jaresova A, Warda H, Macharia A, Hacker MR, Li J. Comparison of Trendelenburg angle in vaginal, laparoscopic, and robotic uterovaginal apical prolapse repairs. Journal of Minimally Invasive Gynecology, 2021;28(11):1868-1875.

Winkelman WD, Demtchouk VO, Brecher LG, Erlinger AP, Modest AM, Rosenblatt PL. Long-term fecal incontinence, recurrence, satisfaction, and regret after the transobturator postanal sling procedure. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(4):244-248.

Winkelman WD, Hacker MR, Anand M, Lefevre R, Richardson ML. Racial and ethnic disparities in obliterative procedures for the treatment of vaginal prolapse. Female Pelvic Medicine and Reconstructive Surgery, 2021;27(12):e710-e715.

Siddique M, Ringel NE, de Winter KL, Marczak T, Kisby C, Rutledge E, Soriano A, Samimi P, Schroeder M, Handler S, Chou J, Gutman RE. Postoperative urinary incontinence in diabetic patients undergoing pelvic reconstructive surgery. Female Pelvic Medicine & Reconstructive Surgery, 2022;28(6):372-378.

Ringel NE, de Winter KL, Siddique M, Marczak T, Kisby C, Rutledge E, Soriano A, Samimi P, Schroeder M, Handler S, Zeymo A, Gutman RE. Surgical outcomes in urogynecology-assessment of perioperative and postoperative complications relative to preoperative hemoglobin a1c-a fellows pelvic research network study. Female Pelvic Medicine & Reconstructive Surgery, 2022; 28(1):7-13.

Kopcsay KS, Marczak TD, Jeppson PC, Cameron AP, Khavari R, Tefera E, Gutman RE. Treatment of refractory overactive bladder with OnabotulinumtoxinA vs PTNS: TROOP trial. International Urogynecology Journal, 2022;33(4):851-860.

Noor N, Bastawros D, Florian-Rodriguez M, Hobson D, Eto C, Lozo S, Lavelle E, Antosh D, Hacker MR, Elkadry E, Von Bargen E. Comparing minimally invasive sacrocolpopexy to vaginal uterosacral ligament suspension: A multicenter retrospective cohort study through the Fellows’ Pelvic Research Network. Female Pelvic Medicine and Reconstructive Surgery, 2022. In press.

Farid H, Bain P, Huang G. A scoping review of peer mentoring in medicine. The Clinical Teacher, 2022; e13512. Epub ahead of print.

Farid H, Blake R, Hacker MR, Erlinger AL, Modest AM. Strategies to improve postpartum glucose screening rates are needed. Journal of Obstetrics and Gynaecology Research, 2021;47(8):2641-2645.

Haviland MJ, Nillni YI , Fox MP, Savitz DA, Hatch EE, Rothman KJ, Hacker MR, Wang TR, Wise LA. Psychotropic medication use during pregnancy and gestational age at delivery. Annals of Epidemiology, 2021;53:34-41. PMCID: PMC7736493

Farid H, Stack-Dunnbier H, Molina R, Nosal C, Mendiola M, Hacker MR. Discrimination, microaggressions, and perceptions of institutional response in an academic obstetrics and gynecology department. Cureus, 2021;13(6):e15993.

Edmonds JK, Woodbury SR, Lipsitz SR, Weiseth A, Farrell ME, Shah NT, Greene N, Gregory KD. Comparing methods of identifying outlying nurses in audits of low-risk cesarean delivery rates. Journal of Nursing Care Quality, 2022;37(2):149-154.

Bosquet-Enlow M, Petty CR, Hacker MR, Burris HH. Maternal psychosocial functioning, obstetric health history, and newborn telomere length. Psychoneuroendocrinology, 2021;123:105043.

Farrell ME, Lutgendorf MA. Term singleton vertex cesarean birth rates in the military health system. The Journal of Perinatal and Neonatal Nursing, 2021;35(4):313-319.

Reynolds E, Weinstein A, Farid H, Libman H. When and how would you screen this patient for cervical cancer? Beyond the guidelines. Annals of Internal Medicine, 2022;175(2):267-75.

DeCarlo C, Boitano LT, Molina RL, Weinberg I, Conrad MF, Eagleton MJ, Dua A. Pregnancy and preeclampsia are associated with acute adverse peripheral arterial events. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021;41(1):526-533.

Landry AM, Molina RL, Marsh R, Hartswick E, Sandoval RS, Osman N, Fernandez L. How should health professional education respond to widespread racial and ethnic health inequity and police brutality? AMA Journal of Ethics, 2021;23(2):E120-124.

Luckett R, Painter H, Hacker MR, Simon B, Seiphetlheng A, Erlinger A, Eakin C, Moyo S, Tumwine Kyokunda L, Esselen K, Feldman S, Morroni C, Ramogola-Masire D. Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at one year in women living with human immunodeficiency virus: A prospective cohort study. British Journal of Obstetrics and Gynaecology, 2021;128(12):1986-1996.

McCloskey L, Bernstein J, Amutah-Onukagha N, Anthony J, Barger M, Belanoff C, Bennett T, Bird CE, Bolds D, Brenna BW, Carter R, Celi A, Chachere B, Crear-Perry J, Crossno C, Cruz-Davis A, Damus K, Dangel A, Depina Z, Deroze P, Dieujuste C, Dude A, Edmonds J, Enquobahrie D, Eromosele E, Ferranti E, Fitzmaurice M, Gebel C, Blount LG, Greiner A, Gullo S, Haddad A, Hall N, Handler A, Headen I, Heelan-Fancher L, Hernandez T, Johnson K, Jones E, Jones N, Klaman S, Lund B, Mallampalli M, Marcelin L, Marshall C, Maynard B, McCage S, Mitchell S, Molina R, Montasir S, Nicklas J, Northrup A, Norton A, Oparaeke E, Ramos A, Rericha S, Rios E, Bloch JR, Ryan C, Sarfaty S, Seely E, Souter V, Spain M, Spires R, Theberge S, Thompson T, Wachman M, Yarrington T, Yee LM, Zera C, Clayton J, Lachance C. Bridging the chasm between pregnancy and health over the life course: A national agenda for research and action. Womens Health Issues, 2021;31(3):204-218.

Murray Horwitz ME, Molina RL, Battaglia TA. Preventing chronic diseases after complicated pregnancies in the COVID-19 era: A call to action for PCPs. Journal of General Internal Medicine, 2021;36(7):2127-2129. PMCID: PMC8006867

Schaefer KM, Modest AM, Hacker MR, Chie L, Connor Y, Golen T, Molina RL. Language preference and risk of primary cesarean delivery: A retrospective cohort study. Maternal and Child Health Journal, 2021;25(7):1110-1117.

Farid H, Stack-Dunnbier H, Molina R, Nosal C, Mendiola M, Hacker MR. Discrimination, microaggressions, and perceptions of institutional response in an academic obstetrics and gynecology department. Cureus, 2021;13(6):e15993.

Johnson KM, Zash R, Modest AM, Luckett R, Diseko M, Mmalane M, Makhema J, Masire-Ramogola D, Wylie BJ, Shapiro R. Anti-hypertensive use for non-severe gestational hypertension in Botswana: A case-control study. International Journal of Gynecology and Obstetrics, 2022;156(3):481-487. PMCID: PMC8855659

Sharma V, Oo PP, Hollaender J, Scott J. COVID-19 and a coup: Blockage of internet and social media access further exacerbate gender-based violence risks for women in Myanmar. BMJ Global Health, 2021;6:e006564.

Molina RL, Benski AC, Bobanski L, Tuller DE, Semrau KEA. Adaptation and implementation of the WHO Safe Childbirth Checklist around the world. Implementation Science Communications, 2021;2(1):76. PMCID: PMC8268383

Delaney MM, Kalita T, Hawrusik B, Neal BJ, Miller K, Ketchum R, Molina RL, Singh S, Kumar V, Semrau KEA. Modification of oxytocin use through a coaching-based intervention based on the WHO Safe Childbirth Checklist in Uttar Pradesh, India: A secondary analysis of a cluster randomized controlled trial. British Journal of Obstetrics and Gynaecology, 2021;128(12):2013-2021.

Baye E, Abate FW, Eglovitch M, Shiferie F, Olson IE, Shifraw T, Kidane WT, Yibeltal K, Tsegaye S, Derebe MM, Isanaka S, Wylie BJ, Molina RL, Chan GJ, Worku A, Mullany LC, Worku A, Berhane Y, Lee ACC. Effect of birthweight measurement quality improvement on low birthweight prevalence in rural Ethiopia. Population Health Metrics, 2021;19(1):35. PMCID: PMC8459538

Sharma V, Gompers A, Kelly J, Patrick E, Heckman C, Solomon A, Scott J. Gender-based violence risk mitigation by non-GBV specialists prior to and during COVID-19: A global survey of knowledge, attitudes, and practices of humanitarian practitioners. International Journal of Environmental Research and Public Health, 2021;18(24):13387.

Bass MB, Molina RL, Reardon EE, Porcello L, Goldberg J, Nickum A, Lipke L, Zeigen L, Eldredge JD, Wallerstein NB. Trends in…controlled vocabulary and health equity. Medical Reference Services Quarterly, 2022;41(2):185-201.

Esselen KM, Stack-Dunnbier H, Gompers A, Hacker MR. Crowdsourcing to measure financial toxicity in gynecologic oncology. Gynecologic Oncology, 2021;161(2):595-600.

Luckett R, Painter H, Hacker MR, Simon B, Seiphetlheng A, Erlinger A, Eakin C, Moyo S, Tumwine Kyokunda L, Esselen K, Feldman S, Morroni C, Ramogola-Masire D. Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at one year in women living with human immunodeficiency virus: A prospective cohort study. British Journal of Obstetrics and Gynaecology, 2021;128(12):1986-1996.

Esselen KM, Gompers A, Hacker MR, Bouberhan S, Shea M, Summerlin SS, Rucker LR, Huh WK, Pisu M, Liang MI. Evaluating meaningful levels of financial toxicity in gynecologic cancers. International Journal of Gynecological Cancer, 2021;31(6):801-806.

Joshi A, Aluko A, Styer AK, Young BC, Johnson KM, Hacker MR, Modest AM. Polycystic ovary syndrome and the risk of preeclampsia. Reproductive Biomedicine Online, 2022. In press.

Hachmann NP, Miller J, Collier AY, Ventura JD, Yu J, Rowe M, Bondzie EA, Powers O, Surve N, Hall K, Barouch DH. Neutralization escape by the SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5. New England Journal of Medicine, 2022;387(1):86-88. PMCID: PMC9258748

Lee AJ, Young BC. Maternal mastectomy in the third trimester: Effects on fetal monitoring. Neoreviews, 2022;23 (6):e419–e424.

Johnson KM, Zash R, Modest AM, Luckett R, Diseko M, Mmalane M, Makhema J, Masire-Ramogola D, Wylie BJ, Shapiro R. Anti-hypertensive use for non-severe gestational hypertension in Botswana: A case-control study. International Journal of Gynecology and Obstetrics, 2022;156(3):481-487. PMCID: PMC8855659

Brown AD, Hart JM, Modest AM, Hess PE, Abbas AM, Nieto-Calvache AJ, Bhide A, Lim B, Dunjin C, Palacios-Jaraquemada J, Sentilhes L, Soma-Pillay P, Aryananda RA, Hantoushzadeh S, Wang S, Shamshirsaz AA, Shainker SA. Geographical variation in management of patients with placenta accreta spectrum: An international survey of experts (GPASS).International Journal of Gynaecology and Obstetrics, 2022;158(1):129-136.

Levitus M, Shainker SA, Colvin MA. COVID-19 in the critically ill pregnant patient. Critical Care Clinics, 2022;38(3):521-534. PMCID: PMC8743466

Collier AY, Yu J, McMahan K, Liu J, Atyeo C, Ansel J, Fricker ZP, Pavlakis M, Curry M, Jacob-Dolan C, Patel H, Sellers D, Barrett J, Rowe M, Ahmad K, Gompers A, Aguayo R, Chandrashekar A, Alter G, Hacker MR, Barouch DH. Coronavirus disease 2019 messenger RNA vaccine immunogenicity in immunosuppressed individuals. The Journal of Infectious Diseases, 2022;225(7):1124-1128. PMCID: PMC8690024

Reforma LG, Febres-Cordero D, Trochtenberg A, Modest AM, Collier AY, Spiel MH. Incidence of small-for-gestational-age infant birthweight following early intertwin fetal growth discordance in dichorionic and monochorionic twin pregnancies. American Journal of Obstetrics and Gynecology, 2022;226(5):726.e1-726.e9.

Johnson KM, Specht AJ, Hart JM, Salahuddin S, Erlinger AL, Hacker MR, Woolf AD, Hauptman M, Karumanchi SA, O’Brien K, Wylie BJ. Risk factor-based lead screening and correlation with blood lead levels in pregnancy. Maternal and Child Health Journal, 2022;26(1):185-192.

Lohman-Payne B, Koster J, Gabriel B, Chilengi R, Forman LS, Heeren T, Duffy CR, Herlihy J, Crimaldi S, Gill C, Chavuma R, Mwananyanda L, Thea DM. Persistent immune activation in human immunodeficiency virus-infected pregnant women starting combination antiretroviral therapy after conception. The Journal of Infectious Diseases, 2022;225(7):1162-1167. PMCID: PMC8974832

Leung M, Weisskopf MG, Laden F, Coull BA, Modest AM, Hacker MR, Wylie BJ, Wei Y, Schwartz J, Papatheodorou S. Exposure to PM2.5 during pregnancy and fetal growth in eastern Massachusetts, USA. Environmental Health Perspectives, 2022;130(1):017004. PMCID: PMC8734565

Salmanian B, Shainker SA, Seaman RD, Modest AM, Castro E, Hecht J, Tounsi S, Mesh N, Brown A, Clark S, Fox KA, Belfort MA, Shamshirsaz AA. The Society for Pediatric Pathology Task Force grading system for placenta accreta spectrum and its correlation with clinical outcomes. American Journal of Obstetrics and Gynecology, 2022;226(5):720.e1-720.e6.

Liu J, Chandrashekar A, Sellers D, Barrett J, Jacob-Dolan C, Lifton M, McMahan K, Sciacca M, VanWyk H, Wu C, Yu J, Collier AY, Barouch DH. Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron. Nature, 2022;603(7901):493-496. PMCID: PMC8930761

Collier AY, Brown CM, Mcmahan K, Yu J, Liu J, Jacob-Dolan C, Chandrashekar A, Tierney D, Ansel JL, Rowe M, Sellers D, Ahmad K, Aguayo R, Anioke T, Gardner S, Siamatu M, Bermudez Rivera L, Hacker MR, Madoff LC, Barouch DH. Characterization of immune responses in fully vaccinated individuals following breakthrough infection with the SARS-CoV-2 Delta variant. Science Translational Medicine, 2022;14(641):eabn6150. PMCID: PMC8995036

Yu J, Collier AY, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. Neutralizing of the SARS-CoV-2 Omicron BA.1 and BA.2 variants. The New England Journal of Medicine, 2022;386(16):1579-1580. PMCID: PMC9006770

Modest AM, Smith LH, Toth T, Collier AC, Hacker MR. Multifoetal gestations mediate the effect of in vitro fertilization (IVF) on ischemic placental disease in autologous oocyte IVF more than donor oocyte IVF. Paediatric and Perinatal Epidemiology, 2022;36(2):181-189. PMCID:PMC8881400

Mitchell SJM, Ngo MG, Maurel MKA, Hasegawa J, Arakaki T, Melcer Y, Maymon R, Vendittelli F, Shamshirsaz AA, Erfani H, Shainker SA, Saad AF, Treadwell MC, Roman AS, Stone JL, Rolnik DL. Timing of birth and adverse pregnancy outcomes in cases of prenatally diagnosed Vasa Previa: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology, 2022;S0002-9378(22)00177-6.

Fruh V, Preston EV, Quinn MR, Hacker MR, Wylie BJ, O’Brien K, Hauser R, James-Todd T, Mahalingiah S. Urinary phthalate metabolite concentrations and personal care product use during pregnancy: Results of a pilot study. Science of the Total Environment, 2022;835:155439.

Declercq ER, Cabral H J, Cui, X, Liu CL, Amutah-Onukagha N, Larson E, Meadows A, Diop H. Using longitudinally linked data to measure severe maternal morbidity. Obstetrics and Gynecology, 2022;139(2):165-171.

Royce CS, Everett EN, Craig AB, Fleming A, Forstein DA, Graziano SC, Hampton BS, Hopkins L, Mckenzie M, Morgan HK, Sims SM, Morosky C. To the point: Advising students applying to obstetrics and gynecology residency in 2020 and beyond. American Journal of Obstetrics and Gynecology, 2021;224(2):148-157. PMCID: PMC7539929

Mendiola M, Modest AM, Huang GC. Striving for diversity: National survey of OB-GYN program directors reporting residency recruitment strategies for underrepresented minorities. Journal of Surgical Education, 2021;78(5):1476-1482.

Farid H, Stack-Dunnbier H, Molina R, Nosal C, Mendiola M, Hacker MR. Discrimination, microaggressions, and perceptions of institutional response in an academic obstetrics and gynecology department. Cureus, 2021;13(6):e15993.

Mendiola M, Modest AM, Huang GC. An inside look: Qualitative study of underrepresented in medicine recruitment strategies used by OB-GYN program directors. Journal of Surgical Education, 2022;79(2):383-388.

Mendiola M, Modest AM, Huang GC. Recruitment of underrepresented in medicine applicants to US internal medicine residencies: Results of a national survey. The American Journal of Medicine, 2022;135(6):787-794.

Seidler EA, Sanchez T, Venturas M, Sakkas D, Needleman DJ. Non-invasive imaging of mouse embryo metabolism in response to induced hypoxia. Journal of Assisted Reproduction and Genetics, 2020;37(8):1797-1805. PMCID: PMC7468040.

Collier AY, Smith LA, Karumanchi SA. Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy. Human Immunology, 2021;82(5):362-370.

Aluko A, Vaughan D, Modest AM, Penzias AS, Hacker MR, Thornton K, Sakkas D. Multiple cryopreservation-warming cycles, coupled with blastocyst biopsy, negatively affect IVF outcomes. Reproductive Biomedicine Online, 2021;42(3):572-578.

Johnson KM, Smith L, Modest AM, Salahuddin S, Karumanchi SA, Rana S, Young BC. Angiogenic factors and prediction for ischemic placental disease in future pregnancies. Pregnancy Hypertension, 2021;25:12-17. PMCID: PMC8363546

Yeh JC, Urman AR, Besaw RJ, Dodge LE, Lee KA, Buss MK. Differential impact of inpatient and outpatient palliative care on end-of-life outcomes for hospitalized patients with cancer. Journal of Clinical Oncology, 2021. In press.

Vaughan DA, Yin SH, Shah JS, Gompers A, Hacker MR, Sakkas D, Domar AD, Toth TL. Telemedicine for reproductive medicine: Pandemic and beyond. Journal of Assisted Reproduction and Genetics, 2022;39(2):327-329. PMCID: PMC8756755

Domar AD, Shah JS, Gompers A, Meyers AJ, Khodakhah DR, Hacker MR, Penzias AS, Sakkas D, Toth TL, Vaughan DA. The psychological impact of the COVID-19 pandemic on women pregnant following ART: A longitudinal study. F&S Reports, 2022;3(1):71-78.

Modest AM, Smith LH, Toth T, Collier AC, Hacker MR. Multifoetal gestations mediate the effect of in vitro fertilization (IVF) on ischemic placental disease in autologous oocyte IVF more than donor oocyte IVF. Paediatric and Perinatal Epidemiology, 2022;36(2):181-189. PMCID:PMC8881400

Shah JS, Dodge LE, Vaughan DA, Rooney KL, Penzias AS, Domar AD. Impact of empathic physician contact on patient anxiety and distress during the waiting period after embryo transfer: A randomized controlled trial. Reproductive Biomedicine Online, 2022;S1472-6483(22)00296-6. Epub ahead of print.

Shah JS, Vaughan DA, Dodge LE, Leung A, Korkidakis A, Sakkas D, Ryley DA, Penzias AS, Toth TL. Endometrial compaction does not predict live birth in single euploid frozen embryo transfers: A prospective study. Human Reproduction, 2022;37(5):980-987.