About the Division  


History

The Center for Hemostasis and Thrombosis Research was founded in 1975 at Tufts University School of Medicine and New England Medical Center by Drs. Bruce and Barbara C. Furie. This laboratory has been committed to an interdisciplinary approach to the study of blood coagulation, platelet and vascular biology. The Center moved in late 1997 to its current location at Harvard Medical School within the Beth Israel Deaconess Medical Center. It become the Division of Hemostasis and Thrombosis in late 2000, and the Furies served as Co-Directors until quite recently. The Center/Division has a long training history in the field of blood coagulation and vascular biology with close to 100 postdoctoral and predoctoral trainees engaged in research over the years.

Organization 

In 2017, Dr. Robert Flaumenhaft took over as the Chief of the Division of Hemostasis and Thrombosis, having worked with the Furies for many years. Dr. Flaumenhaft is a cell biologist focused on granule secretion mechanisms in platelets. The Division's investigators also include Drs. Bruce Furie, Kenneth Bauer, Natalie Beglova, Mingdong Huang and Jeffrey Zwicker. Read more about our division members

Funding

The Division for Hemostasis and Thrombosis is primarily funded by grants from the National Heart Lung and Blood Institute, National Institutes of Health. The Center has been the recipient of support from the Howard Hughes Medical Institute, the National Hemophilia Foundation and Burroughs-Welcome.

Facilities & Equipment 

The Division maintains core facilities for modern molecular biology, protein chemistry and cell biology research. Laboratory facilities include protein sequencing, peptide synthesis, DNA synthesis, flow cytometry, computer-based molecular graphics, a leukocyte rolling video station, and fluorescence and UV spectroscopy.

The Division occupies approximately 7,500 square feet of laboratory and office space in Research East, adjacent to the Harvard Medical School quadrangle. The Center facilities include the resources for modern biomedical research: a Becton Dickinson FACSCalibur flow cytometer, an Applied Biosystems Procise HT protein sequencer, two Applied Biosystems peptide synthesizer, an SLM 8000C spectrofluorometer with stopped flow accessory, an AVIV 118 spectrophotometer, a Varian Unity Inova 500 MHz NMR spectrometer, three Silicon Graphic computer workstations, two Sun workstations and several high end PC-based workstations.

A new confocal and widefield intravital microscopy facility for fluorescence and brightfield digital imaging has recently been completed. Miscellaneous equipment in the Center includes a Zeiss fluorescence microscope, a Milligen Cytofluor fluorescence ELISA reader, a Molecular Devices THERMOMax kinetic microELISA reader, a Coulter counter, a Pharmacia PhastSystem, high speed refrigerated centrifuges, HPLC systems, a Beckman DU6 spectrophotometer, a Packard $-scintillation spectrometer, and a Packard 5500 Autogamma spectrometer. A core transgenic facility for the preparation of mice with specific gene knockouts or transgenic mice is operated by the institution as a shared resource.

The Beth Israel Deaconess Medical Center includes modern animal facilities, a media center for the preparation of bacterial and mammalian culture media, dish washing facilities, and shared conference rooms. In addition, dark rooms, X-ray developing facilities, DNA sequencing, cell sorting, mass spectroscopy and electron microscopy are among shared resources of the institution.

Research Community 

BIDMC is a major biomedical research institution, and derives over $130 million per year from extramural sources, including over $80 million per year from the NIH, for its research programs. Part of BIDMC and Harvard Medical School-affiliated, the Division is also in close proximity to Brigham and Women's Hospital, the Dana Farber Cancer Institute and Boston Children's Hospital. The critical mass of outstanding biomedical research in the Longwood Medical Area is of great advantage to this program. This is a unique and extraordinarily rich environment for research and educational activities in the biomedical sciences.