Study of a New Use of an Add-On Drug in the Early Phase of Psychosis (NAC Study)
Larry Seidman, Ph.D.
We are studying a nutritional supplement called N-Acetyl-Cysteine (or
“NAC”) as a novel adjunct in the treatment of symptoms and deficits in
early psychosis. NAC works as an anti-oxidant and is thought to potentially
increase glutathione, which is important to overall brain function, during
a critical period of brain development. Previous research using add-on NAC
treatment in individuals with long term psychosis found improvement of
symptoms and a reduction of side-effects.
What will happen during the study?
The study involves a 28 week, double-blind trial of add-on NAC or placebo
in the treatment of individuals experiencing early psychosis. NAC or
placebo will be taken in the form of an effervescent tablet, which is
dissolved in water.
As a participant, you would be asked to:
Sign a consent form indicating your agreement to participate.
Participate in about 9-10 study visits every 4 weeks for 28 weeks.
Take part in:
An initial set of personal interviews
Brief interviews every 4 weeks throughout the duration of the
Paper and pencil tests of your attention, thinking and memory
Blood tests and a specialized EEG during the screening and last
Continue your usual medication treatment by your doctor.
Who can participate?
Individuals between the ages of 18-35 who may have recently been
hospitalized for a psychotic disorder, or who are currently experiencing
early symptoms of psychosis, including:
Ideas or beliefs that others may find unusual or too intense
Suspiciousness or uneasiness with others
Hallucinations or confused thinking
Having trouble thinking clearly, focusing or concentrating
This study takes place at the Massachusetts Mental Health Center and Beth
Israel Deaconess Medical Center, East Campus. Individuals who complete all
parts of the study will be compensated $315 or more for their
For more information, please contact:
at (617) 754-1224
or by email at email@example.com
at (617) 754-1237
or by email at firstname.lastname@example.org
To view the brochure click on the link: