Efficacy of CTRA as a New Tool to Assess Fracture Risk in Patients with Skeletal Metastasis


Learn more about CTRA

Dear Collaborators:
Thank you very much for agreeing to enroll in our study. The best place for you to start is by reviewing the study fact sheet, the patient enrollment steps, the CT imaging protocol and the grant proposal to further familiarize yourself with the project. Before you can proceed any further, you must submit an IRB protocol to your institution to be able to enroll patients in the study. As this project proposes only to perform image processing on patient CT data that will be obtained as part of the patient care process, you can apply for expedited review, should your institution offer such an option. As part of the study, we'd like to request that the patients fill in the Short Form 36 (general health survey) and the WOMAC questionnaires (for appendicular skeleton). So, please ensure that the forms are added to your IRB proposal.

Once you have obtained IRB approval, you can start enrolling patients into the study. You'll find all necessary forms and information in the left column of this page. You'll need to fill out the patient info sheet to provide us with basic and anonymous patient information and the Pre-SRA questionnaire and send them along with the patient CT data on a CD/ DVD to the address below. Once you have received the SRA analysis report, then you'll then send us the Post-SRA questionnaire highlighting the influence of the SRA analysis on your patient care decision making process. You can fax the data sheets to us at the number below; however, we would much rather receive the forms via e-mail to reduce errors. This process will be completely online in the near future, when we move to an all-online platform for uploading of data.

Please send CT data and other info via courier to:

Ara Nazarian
Center for Advanced Orthopaedic Studies
99 Brookline Avenue, RN115
Boston, MA 02215
p: 617.667.8512 / 617.650.1224
f: 617.667.7175
e: anazaria@bidmc.harvard.edu

Participating Institutions


  • Department of Orthopaedic Surgery, Upstate Medical University
  • Department of Orthopaedic Surgery, Rhode Island Hospital
  • Department of Orthopaedic Surgery, University of Minnesota Medical Center
  • Department of Orthopaedic Surgery, McGill University Health Centre
  • Department of Orthopaedic Surgery, Sinai Hospital of Baltimore
  • Section of Orthopaedic Oncology, University of Texas, M. D. Anderson Cancer Center
  • Department of Orthopaedic Surgery, Edwards Comprehensive Cancer Center, Marshall University
  • Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center
  • Department of Orthopaedic Surgery, Huntsman Cancer Institute & Primary Children's Medical Center, University of Utah
  • Department of Orthopaedic Surgery, Mayo Clinic
  • Dana-Farber Cancer Institute