Publications

Insight Into Reduction of Wakefulness by Suvorexant in Patients With Insomnia: Analysis of Wake Bouts. Svetnik V, Snyder ES, Tao P, Scammell TE, Roth T, Lines C, Herring WJ. Sleep. 2018 Jan 1;41(1). PMID: 29112763

Dysregulation of Sleep Behavioral States in Narcolepsy. Schoch SF, Werth E, Poryazova R, Scammell TE, Baumann CR, Imbach LL. Sleep. 2017 Dec 1;40(12). PMID: 29029348

Decreased alertness due to sleep loss increases pain sensitivity in mice. Alexandre C, Latremoliere A, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ. Nat Med. 2017 Jun;23(6):768-774. PMID: 28481358

Cataplexy and Its Mimics: Clinical Recognition and Management. Pillen S, Pizza F, Dhondt K, Scammell TE, Overeem S. Curr Treat Options Neurol. 2017 Jun;19(6):23. PMID: 28478511

GABAergic Neurons of the Central Amygdala Promote Cataplexy. Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE. J Neurosci. 2017 Apr 12;37(15):3995-4006. PMID: 28235898

Neural Circuitry of Wakefulness and Sleep. Scammell TE, Arrigoni E, Lipton JO. Neuron. 2017 Feb 22;93(4):747-765. PMID: 28231463

Complementary roles of gasotransmitters CO and H2S in sleep apnea. Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1413-1418. PMID: 28115703

Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice. Kroeger D, Ferrari LL, Petit G, Mahoney CE, Fuller PM, Arrigoni E, Scammell TE. J Neurosci. 2017 Feb 1;37(5):1352-1366. PMID: 28039375

Descending projections from the basal forebrain to the orexin neurons in mice. Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. J Comp Neurol. 2017 May 1;525(7):1668-1684. PMID: 27997037

Dynamic GABAergic afferent modulation of AgRP neurons. Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG Jr, Andermann ML, Krashes MJ, Lowell BB. Nat Neurosci. 2016 Dec;19(12):1628-1635. PMID: 27643429

Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury. Valko PO, Gavrilov YV, Yamamoto M, Noaín D, Reddy H, Haybaeck J, Weis S, Baumann CR, Scammell TE. Sleep. 2016 Jun 1;39(6):1249-52. PMID: 27091531

Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area. Gavrilov YV, Ellison BA, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE, Valko PO. Sleep. 2016 May 1;39(5):1059-62. PMID: 26951397

Narcolepsy. Scammell TE. N Engl J Med. 2015 Dec 31;373(27):2654-62. PMID: 26716917

Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. Perez MV, Pavlovic A, Shang C, Wheeler MT, Miller CL, Liu J, Dewey FE, Pan S, Thanaporn PK, Absher D, Brandimarto J, Salisbury H, Chan K, Mukherjee R, Konadhode RP, Myers RM, Sedehi D, Scammell TE, Quertermous T, Cappola T, Ashley EA. J Am Coll Cardiol. 2015 Dec 8;66(22):2522-33. PMID: 26653627

Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms. Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E. J Physiol. 2016 Feb 15;594(4):1069-85. PMID: 26613645

Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R41-54. PMID: 26491097

Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1β: Investigating a Method for the Study of Fatigue in Laboratory Animals. Bonsall DR, Kim H, Tocci C, Ndiaye A, Petronzio A, McKay-Corkum G, Molyneux PC, Scammell TE, Harrington ME. PLoS One. 2015 Oct 15;10(10):e0140678. PMID: 26469939

Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness. Branch AF, Navidi W, Tabuchi S, Terao A, Yamanaka A, Scammell TE, Diniz Behn C. Sleep. 2016 Feb 1;39(2):369-77. PMID: 26446125

Bradysomnia in Parkinson's disease. Imbach LL, Sommerauer M, Poryazova R, Werth E, Valko PO, Scammell TE, Baumann CR. Clin Neurophysiol. 2016 Feb;127(2):1403-1409. PMID: 26419612

Overview of sleep: the neurologic processes of the sleep-wake cycle. Scammell TE. J Clin Psychiatry. 2015 May;76(5):e13. PMID: 26035194

The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB. Brain Behav Immun. 2015 Jul;47:172-7. PMID: 25532785

Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury. Valko PO, Gavrilov YV, Yamamoto M, Finn K, Reddy H, Haybaeck J, Weis S, Scammell TE, Baumann CR. Ann Neurol. 2015 Jan;77(1):177-82. PMID: 25363332

Usefulness of a Nocturnal SOREMP for Diagnosing Narcolepsy with Cataplexy in a Pediatric Population. Reiter J, Katz E, Scammell TE, Maski K. Sleep. 2015 Jun 1;38(6):859-65. PMID: 25325489

SCOPRISM: a new algorithm for automatic sleep scoring in mice. Bastianini S, Berteotti C, Gabrielli A, Del Vecchio F, Amici R, Alexandre C, Scammell TE, Gazea M, Kimura M, Lo Martire V, Silvani A, Zoccoli G. J Neurosci Methods. 2014 Sep 30;235:277-84. PMID: 25092499

Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Baumann CR, Mignot E, Lammers GJ, Overeem S, Arnulf I, Rye D, Dauvilliers Y, Honda M, Owens JA, Plazzi G, Scammell TE. Sleep. 2014 Jun 1;37(6):1035-42. PMID: 24882898

Optogenetic-mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal. Williams RH, Chee MJ, Kroeger D, Ferrari LL, Maratos-Flier E, Scammell TE, Arrigoni E. J Neurosci. 2014 Apr 23;34(17):6023-9. PMID: 24760861

Delusional confusion of dreaming and reality in narcolepsy. Wamsley E, Donjacour CE, Scammell TE, Lammers GJ, Stickgold R. Sleep. 2014 Feb 1;37(2):419-22. PMID: 24501437

Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord. Weng FJ, Williams RH, Hawryluk JM, Lu J, Scammell TE, Saper CB, Arrigoni E. J Physiol. 2014 Apr 1;592(7):1601-17. PMID: 24344163

Emerging therapeutics in sleep. Saper CB, Scammell TE. Ann Neurol. 2013 Sep;74(3):435-40. PMID: 24038193

Increase of histaminergic tuberomammillary neurons in narcolepsy. Valko PO, Gavrilov YV, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE. Ann Neurol. 2013 Dec;74(6):794-804. PMID: 24006291

Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice. Kantor S, Mochizuki T, Lops SN, Ko B, Clain E, Clark E, Yamamoto M, Scammell TE. Sleep. 2013 Aug 1;36(8):1129-38. PMID: 23904672

Role of the medial prefrontal cortex in cataplexy. Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE. J Neurosci. 2013 Jun 5;33(23):9743-51. PMID: 23739971

Amygdala lesions reduce cataplexy in orexin knock-out mice. Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE. J Neurosci. 2013 Jun 5;33(23):9734-42. PMID: 23739970

Control of arousal by the orexin neurons. Alexandre C, Andermann ML, Scammell TE. Curr Opin Neurobiol. 2013 Oct;23(5):752-9. 15. Review. PMID: 23683477

Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. Poli F, Overeem S, Lammers GJ, Plazzi G, Lecendreux M, Bassetti CL, Dauvilliers Y, Keene D, Khatami R, Li Y, Mayer G, Nohynek H, Pahud B, Paiva T, Partinen M, Scammell TE, Shimabukuro T, Sturkenboom M, van Dinther K, Wiznitzer M, Bonhoeffer J. Vaccine. 2013 Jan 30;31(6):994-1007. PMID: 23246545

Inter-hemispheric oscillations in human sleep. Imbach LL, Werth E, Kallweit U, Sarnthein J, Scammell TE, Baumann CR. PLoS One. 2012;7(11):e48660. PMID: 23144920

Narcolepsy: neural mechanisms of sleepiness and cataplexy. Burgess CR, Scammell TE. J Neurosci. 2012 Sep 5;32(36):12305-11. PMID: 22956821

Neural circuitry engaged by prostaglandins during the sickness syndrome. Saper CB, Romanovsky AA, Scammell TE. Nat Neurosci. 2012 Jul 26;15(8):1088-95. PMID: 22837039

Sleep neurobiology from a clinical perspective. España RA, Scammell TE. Sleep. 2011 Jul 1;34(7):845-58. PMID: 21731134

Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Scott MM, Marcus JN, Pettersen A, Birnbaum SG, Mochizuki T, Scammell TE, Nestler EJ, Elmquist JK, Lutter M. Behav Brain Res. 2011 Sep 23;222(2):289-94. PMID: 21377495