Johannes Schlondorff, MD, PhD
Assistant Professor of Medicine, Harvard Medical School
The overarching goal of the Schlondorff laboratory's research efforts is to understand the normal function of podocytes and their role in maintaining the glomerular filtration barrier. Impaired podocyte function and podocyte loss are thought to be central to the development and progression of proteinuric kidney diseases such as focal segmental glomerulosclerosis (FSGS) and diabetic kidney disease. Through collaborations with Dr. Pollak’s lab, we have focused on developing a mechanistic understanding of the effect of disease-causing human mutations on podocyte function, with the goal of identifying common pathways perturbed in both rare and common kidney diseases. These efforts have largely focused on examining the role of three genes, TRPC6, ACTN4, and INF2, in which mutations are known to cause FSGS. The lab utilizes an array of techniques spanning protein biochemistry, cell biology, and genetically engineered mouse models in our efforts.