S. Ananth Karumanchi, MD 
Professor of Medicine, Harvard Medical School

Dr. Karumanchi’s group first identified pre-eclampsia as a systemic disorder affecting the endothelium, a single cell layer that lines the inner surface of blood vessels. Pre-eclampsia is a late complication affecting 1 out of every 20 pregnancies, and is the single biggest reason for poor fetal outcomes and maternal deaths. Dr. Karumanchi’s group has since discovered molecular methods to diagnose pre-eclampsia in advance, and have investigated new ways to treat the disease, extend pregnancy safely, and thereby improve maternal and fetal outcomes. What was once a devastating disease of mysterious origin may now be on the cusp of a full molecular understanding accompanied by a first-in-kind treatment for expectant mothers.

Harvard Catalyst