SeijiDr. Arai worked and performed research on urological cancer as a urologist in Japan. He was focusing on analytical methods for steroid hormones (adrenal androgens, testosterone, DHT and estradiol) in the prostate and steroidogenesis in prostate cancer tissues, especially in castration-resistant prostate cancer (CRPC). His ongoing effort is to study the molecular mechanism of possible therapies (e.g. BH3 mimetics) for prostate cancer.

Email Dr. Arai


Postdoctoral Training: Beth Israel Deaconess Medical Center: 2014-present

Ph.D.: Medical Science (Analytical Chemistry), Gunma University (Japan): 2006-2010

M.D.: Gunma University (Japan): 1997-2003

Grants and Awards:

Young Researcher Award, The Japan Society of Andrology: 2014

Grant-in-Aid for Young Scientists (25861411), Japan Society for the Promotion of Science: 2013-2015

Research Promotion Grant, The Japanese Foundation for Prostate Research: 2013-2014

Publications (click on underlined to go to publication):

1. Shibata Y, Arai S, Honma S. Methodological approach to the intracrine study and estimation of DHEA and DHEA-S using liquid chromatography-tandem mass spectrometry (LC-MS/MS) (2015). J Steroid Biochem Mol Biol. 145:193-199.

2. Magari T, Shibata Y, Arai S, Kashiwagi B, Suzuki K. Time-dependent effects of castration on the bladder function and histological changes in the bladder and blood vessels (2014). Asian J Androl. 16(3): 457-460.

3. Koike H, Nitta T, Sekine Y, Arai S, Furuya Y, Nomura M, Matsui H, Shibata Y, Ito K, Oyama T, Suzuki K. YM155 reverses rapamycin resistance in renal cancer by decreasing survivin (2014). J Cancer Res Clin Oncol. 140(10): 1705-1713.

4. Arai S, Matsui H, Ohki R, Miyazawa Y, Koike H, Hashita T, Katsuyama Y, Sekine Y, Nomura M, Shibata Y, Hatori M, Ito K, Yamamoto K, Ohmori S, Suzuki K. Suicide attempt with an overdose of sunitinib (2014). Br J Clin Pharmacol. 78: 933-935.

5. Shibata Y, Suzuki K, Arai S, Miyoshi Y, Umemoto S, Masumori N, Kamiya N, Ichikawa T, Kitagawa Y, Mizokami A, Sugimura Y, Nonomura N, Sakai H, Honma S, Kubota Y. Impact of pre-treatment prostate tissue androgen content on the prediction of castration-resistant prostate cancer development in patients treated with primary androgen deprivation therapy (2013). Andrology. 1: 505-511.

6. Arai S, Shibata Y, Nakamura Y, Kashiwagi B, Uei T, Tomaru Y, Miyashiro Y, Honma S, Hashimoto K, Sekine Y, Ito K, Sasano H, Suzuki K. Development of prostate cancer in a patient with primary hypogonadism: intratumoural steroidogenesis in prostate cancer tissues (2013). Andrology. 1: 169-174.

7. Arai S, Hasumi M, Shimizu N. Long-term survival and onset of granulomatous pneumonia after lung metastasectomy in a patient with non-muscle-invasive bladder cancer (2012). Int Urol Nephrol. 44: 1383-1387.

8. Arai S, Miyashiro Y, Shibata Y, Tomaru Y, Kobayashi M, Honma S, Suzuki K. Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues (2011). Steroids. 76: 301-308.

9. Arai S, Miyashiro Y, Shibata Y, Kashiwagi B, Tomaru Y, Kobayashi M, Watanabe Y, Honma S, Suzuki K. New quantification method for estradiol in the prostatic tissues of benign prostatic hyperplasia using liquid chromatography-tandem mass spectrometry (2010). Steroids. 75: 13-19.

10. Arai S, Makino T, Okugi H, Hasumi M, Shibata Y, Hatori M, Suzuki K. A case of emphysematous pyelonephritis in a renal allograft (2006). Transplantation. 81: 296-297.

11. Shibata Y, Kashiwagi B, Arai S, Fukabori Y, Suzuki K, Honma S, Yamanaka H. Direct regulation of prostate blood flow by vascular endothelial growth factor and its participation in the androgenic regulation of prostate blood flow in vivo (2004). Endocrinology. 145: 4507-4512.

Link to Dr. Arai's Harvard Catalyst Page