Olga Voznesensky, M.S., Lab Manager
Olga joined Dr. Balk’s lab in 2011 as a research lab manager. Olga is
involved in the studies of androgen receptor signaling and the mechanism of
castration resistance in prostate cancer. Specifically, Olga works with
tissue samples obtained from patients with advanced and metastatic prostate
cancer enrolled in clinical trials. She uses either the whole patient’s
biopsies or isolates tumor cells using laser capture microdissection. She
uses circulating nucleic acids isolated from plasma and circulating tumor
cells as another source of material. Nucleic acids from the samples are
purified and used for analysis of gene expression patterns, mutation
analysis, library preparations for deep sequencing. The goal of these
studies is to understand the role of AR signaling in cancer’s resistance to
treatment.
Olga holds MS degree from Moscow University of Fine Chemical Technology. Olga worked for many years at the University of Connecticut Health Center where she studied molecular mechanisms of bone remodeling and the role of cyclooxygenase-2, prostaglandins and parathyroid hormone in bone formation and resorption. At UCHC Olga also worked on bladder cancer and evaluated expression of potential diagnostic markers of invasive tumors.
Olga has multiple hobbies. She likes to read, travel, and cook. She enjoys outdoor activities: skiing, tennis, hiking and gathering wild mushrooms.
Publications
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Persson E, Voznesensky OS, Huang YF, Lerner UH, Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts, Bone. 2005; 37(4):513-29. PMID: 16085472
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Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshio K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC., Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo, J Bone Miner Res. 2002; 17(8):1430-40. PMID: 12162497
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Okada Y, Voznesensky O, Herschman H, Harrison J, Pilbeam C. Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells. J Cell Biochem. 2000;78(2):197-209. PMID: 10842315.
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Pilbeam C, Rao Y, Voznesensky O, Kawaguchi H, Alander C, Raisz L, Herschman H. Transforming growth factor-beta1 regulation of prostaglandin G/H synthase-2 expression in osteoblastic MC3T3-E1 cells. Endocrinology. 1997;138(11):4672-82. PMID: 9348193.
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Pilbeam CC, Kawaguchi H, Voznesensky OS, Alander CB, Raisz LG. Regulation of inducible prostaglandin G/H synthase by interleukin-1, transforming growth factors-alpha and -beta, and prostaglandins in bone cells. Adv Exp Med Biol. 1997;400B:617-23. PMID: 9547612.
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Kawaguchi H, Nemoto K, Raisz LG, Harrison JR, Voznesensky OS, Alander CB, Pilbeam CC. Interleukin-4 inhibits prostaglandin G/H synthase-2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures. J Bone Miner Res. 1996;11(3):358-66. PMID: 8852946
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Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN, Kawaguchi H. Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res. 1995;10(3):406-14. PMID: 7785462.
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Kawaguchi H, Raisz LG, Voznesensky OS, Alander CB, Hakeda Y, Pilbeam CC. Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae. Endocrinology. 1994;135(3):1157-64. PMID: 8070358. Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O, Alander CB, Raisz LG. Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J Biol Chem. 1993;268(34):25643-9. PMID: 8245000.