Since 40-60% of patients with prostate cancer harbor TMPRSS2/ERG fusion,
which put ERG expression under control of androgen, Dr. Ma's current
efforts focus on studying the contribution of this translocation to
prostate cancer development. By genome wide CHIP sequencing of ERG binding
sites, it was found that in VCAP, a TMPRSS2/ERG fusion prostate cancer cell
line, SOX9 expression was elevated by ERG binding to a SOX9 enhancer and
SOX9 overexpression mimic phenotypes of ERG overexpression, which indicate
SOX9 is a downstream effector of ERG. Therefore, she's actively identifying
SOX9 target genes aiming to elucidate the function of TMPRSS2/ERG fusion in
Email Dr. Ma
AACR-Millennium Fellowships in Prostrate Cancer Research- 2014
Publications (click on underlined to go to publication):
, H. Ye, H. H. He, S. J. Gerrin, S. Chen, B. Tanenbaum, C. Cai,
A. G. Sowalsky, L. He, H. Wang, S. P. Balk, and X. Yuan. SOX9
drives WNT pathway activation in prostate cancer . J Clin
Invest. 2016;126(5):1745-1758. doi:10.1172/JCI78815. Epub 2016
C. Cai, H. Wang, HH He, S. Chen, L. He, F. Ma,
L. Mucci, Q. Wang, C. Fiore, A.G. Sowalsky, M. Loda, X.S. Liu,
M. Brown, S.P. Balk, X. Yuan. ERG induces androgen
receptor-mediated regulation of SOX9 in prostate cancer. J Clin
Invest. 2013 Mar 1;123(3):1109-22. doi: 10.1172/JCI66666. Epub
2013 Feb 15.
M. Sun＊，F. Ma＊, X. Zeng,
Q. Liu, XL. Zhao, FX. Wu, GP. Wu, ZF. Zhang, B. Gu, YF. Zhao,
SH. Tian, B. Lin, XY. Kong, XL. Zhang, W. Yang, W. Lo, X.
Zhang. Triphalangeal thumb-polysyndactyly syndrome and
syndactyly type IV are caused by genomic duplications involving
the long-range, limb-specific SHH enhancer. J Med Genet. 2008
L. Wu, D. Liang, N. Niikawa, F. Ma, M. Sun, Q.
Pan, Z. Long, Z. Zhou, K. Yoshiura, H. Wang, D. Sato, G.
Nishimura, H. Dai, X. Zhang, J. Xia. A ZRS duplication causes
syndactyly type IV with tibial hypoplasia. Am J Med Genet A.
2009 Feb 15;149A(4):816-8.
M. Sun, N. Li, W. Dong, Z Chen, Q. Liu, Y. Xu, G. He, Y. Shi,
X. Li, J. Hao, Y. Luo, D. Shang, D. Lv, F. Ma,
D. Zhang, R. Hua, C. Lu, Y. Wen, L. Cao, AD AD. Irvine, WH.
McLean, Q. Dong, MR. Wang, J. Yu, L. He, WH. Lo, X. Zhang.
Copy-number mutations on chromosome 17q24.2-q24.3 in congenital
generalized hypertrichosis terminalis with or without gingival
hyperplasia. Am J Hum Genet. 2009 Jun;84(6):807-13.
QJ. Liu, F. Ma, D. Li, XW. Wang, WY. Tian, Y.
Chen, JB. Feng, X. Lu, DQ. Chen, XN. Chen, Y. Shen. Detection
of chromosome aberrations in Chinese children with autism using
G-banding and BAC FISH. Chin J Med Genet, 2005 Jun;
QJ. Liu, JB. Feng, X. Lu, XW. Wang, AY. Liu, F. Ma
, SY. Y, Y. Shen. Detection of number abnormity of sex chromosome
in patients with hypogonadia by interphase FISH. Chi J Bir Hea Her.
QJ. Liu, F. Ma, XN. Chen. Research developments of
genetics on autism. For Med Sci (Section of Genetics). 2003; 26(6).
authors contributed equally to the work
Link to Dr. Ma's Harvard Catalyst Page