About the Genetics Division

The Division of Genetics is headed by Pier Paolo Pandolfi, MD, PhD. A world-renowned investigator, Dr. Pandolfi holds the Reisman Endowed Chair of Medicine and is Professor of Pathology at Harvard Medical School. He serves as the Director of the BIDMC Cancer Center, the Cancer Research Institute and the Cancer Genetics Program.

The research carried out in the Genetics Division and Dr. Pandolfi's laboratory has been seminal in elucidating the molecular mechanisms and the genetics underlying the pathogenesis of leukemias, lymphomas and solid tumors as well as in modeling these cancers in mice. Dr. Pandolfi and his colleagues have characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL), as well as of major tumor suppressors such PTEN and p53 and novel proto-oncogenes. The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Novel therapeutic concepts have emerged from this work that are currently been tested in clinical trials.

Read more about Dr. Pandolfi, his team members, and their groundbreaking research and publications.