Dr. Harold Dvorak is Director of the Vascular Biology Center at the Beth Israel Deaconess Medical Center and Professor of Pathology at Harvard Medical School. His research interests have spanned the fields of immunology, inflammation, cancer biology and angiogenesis. His research has done much to elucidate the nature and composition of tumor stroma and the pathogenesis of its generation. Based on quantitative biochemical and pharmokinetic studies, as well as sophisticated morphological analysis, Dr. Dvorak called attention to the similarities between tumor stroma generation and wound healing. In both settings, the initial sequence of events includes vascular hyperpermeability, resulting in extravascular fibrin deposition, as well as the development of an inflammatory response and, ultimately progression to desmoplasia or scar formation. In the course of these investigations, he discovered a key angiogenic mediator, vascular permeability factor/vascular endothelial growth factor (VPF,VEGF, VEGF-A). Based on Dr. Dvorak's work and that of the many other groups now investigating VPF/VEGF, this factor is generally regarded as one of the most important (if not the most important) of the angiogenic factors which contribute to the neovascularization associated with tumor growth, as well as during other adaptive or pathological angiogenic responses.

Dr. Dvorak is the author of nearly 300 original papers and has published many review articles. He has been a member of several NIH and American Cancer Society study sections and has served on the editorial boards of a number of journals. He has been a speaker, organizer and /or chairperson at various Gordon Conferences and Keystone Conferences on cancer, hemostasis, molecular pathology, etc. He has served as President of the American Society of Investigative Pathology, one of the FASEB societies, and recently received that organization's Rous-Whipple Award.

Dr. Lawler serves as Associate Director of the Training Grant. Dr. Lawler is Professor of Pathology at the BIDMC and Harvard Medical School. His work has focused on the role of the members of the thrombospondin gene family in the tissue remodeling that is associated with development, tumor progression, wound healing, synaptogenesis and angiogenesis. He has authored over 150 papers and has served on numerous NIH site visit committees and on the Hematology and Pathology A study sections on an ad hoc basis. He is also chairman of the Vessel Wall Biology II study section of the American Heart Association. Dr. Lawler is co-principal investigator with Dr. Dvorak on the Program Project grant entitled Spatial and Temporal Regulation of Angiogenesis.