New Research is Identifying Diabetes and Heart Disease — Years Before They
What if you could peer into a crystal ball and see whether you would
develop cardiac disease far in the future? What if a fortune teller could
accurately predict whether you would be one of the 29 million individuals
in the U.S. who will develop type 2 diabetes — a decade from now?
It’s not magic: A standard blood sample that measures molecular byproducts
of human metabolism could turn out to hold the answers to our future
A rapidly emerging scientific field known as “metabolomics” is the key to
these and other discoveries. This sophisticated analysis of small molecules
in the blood that determine how the body burns fuel is revealing important
information about individuals’ current and future health. The field holds
promise for providing patients and their doctors with an advance warning
system years before disease strikes.
at Beth Israel Deaconess Medical Center has become a leader in this field
thanks to the recent arrival of
Robert Gerszten, MD
, as Chief of
. He is one of the world’s leading metabolomics researchers. Over the past
decade, his studies have examined hundreds of molecules and revealed some
highly surprising discoveries, including information that predicts which
patients will go on to develop diabetes and cardiac disease.
Creating a Better Blood Test
Every patient who has an annual check-up has blood drawn for a number of
tests. But this routine part of the physical exam currently focuses on just
a small piece of each patient’s cardiac health.
“Right now, a blood sample might be tested for about 10 or 20 different
measurements, including glucose [blood sugar], calcium and cholesterol
levels,” explains Dr. Gerszten (right). “Although high cholesterol is a
major risk factor for heart disease, the truth of the matter is that many
people who develop heart disease often don’t exhibit this or any other
indicator of trouble ahead.”
But Dr. Gerszten predicts that the blood test of the future may reveal
hundreds of potential elements of cardiac disease.
published online this past July in the journal Circulation, Dr.
Gerszten’s research team identified more than 200 new biomarkers linked to
cardiovascular tissue damage. A biomarker is a molecule that is associated
with a distinct condition and can, therefore, help diagnose, monitor and
screen for particular diseases.
“The presence of these new biomarkers in the blood indicated an elevated
risk of cardiac disease even in people who had no outward symptoms,” he
explains. “Using sophisticated new technology, we were able to identify
previously unknown proteins associated with damage to cardiovascular
tissues, including more than 200 proteins that increased within just an
hour of injury to the heart muscle.
“By having this predictive information available years in advance, patients
and their doctors will know when heart disease is first starting to take
hold,” says Dr. Gerszten. “This will provide the opportunity for them to
take preventive steps to intervene very early, well before disease
Interventions might include medications or rigorous lifestyle changes,
including diet and exercise.
Predicting Who Will Develop Diabetes — 10 Years from Now
Heart disease and diabetes often occur together. Over the past decade, Type
2 diabetes has reached epidemic proportions, and according to statistics
from the American Diabetes Association, more than 1.4 million Americans are
diagnosed with diabetes each year.
“Normally the body breaks down food into simple components, such as sugars
and amino acids,
that can be used or stored as fuel,” explains
Anthony Hollenberg, MD
(right), Chief of the Division of
Endocrinology, Diabetes and Metabolism
at BIDMC. “But in people with
diabetes, abnormal chemical reactions in the body disrupt this process, leading to
the accumulation of sugar and risk of serious complications, including
heart disease and stroke.
“We currently diagnose diabetes through blood glucose tests,” adds Dr.
Hollenberg. “But by the time blood glucose levels are high enough to warn
of diabetes, it may have already done its damage. A better understanding of
how this disease progresses from its earliest stages could enable doctors
to help their patients better manage this condition and prevent the
development of dangerous complications.”
This was the challenge that inspired Dr. Gerszten and his research team to
, which led to the discovery that chemical changes begin to take place
nearly 12 years before diabetes symptoms appear.
The scientists used data from the famous
Framingham Heart Study,
which began in 1948 and was the first major research to identify what are
now well-known risk factors for heart disease, such as high blood pressure,
smoking and obesity.
Framingham Makes History Again
“For our work, we used blood samples that were taken in 1994 from two
groups of Framingham participants,” he explains. ”While both groups shared
all of the same characteristics [age, weight, etc.], one group went on to
develop diabetes, while the second group did not.”
Through metabolomics analysis, the researchers looked for differences in
the chemicals from these blood samples. The results were astounding.
“It really was a breakthrough for us,” says Dr. Gerszten. “There were
dramatic differences in the blood samples of these two groups."
The researchers discovered a group of amino acids that were present at much
higher levels in the blood of people who eventually developed diabetes,
compared with people who did not. These biomarkers had not previously been
associated with diabetes. The individuals who had the highest levels of
these amino acids in their blood had an astonishing 400 percent greater
chance of developing diabetes.
A later study in a Swedish population replicated these findings.
Most striking of all was that these differences came from blood samples
taken 12 years before any of the participants were diagnosed with diabetes.
What Lies Ahead
While much of metabolomics work remains in the research stage, scientists
hope that within 10 years, sophisticated blood tests will become as common
in annual physicals as blood pressure checks.
The ultimate goal, says Dr. Gerszten, is to identify key predictors of
heart disease at the earliest possible point, so that patients can take
action before symptoms begin and complications set in.
“There’s no question that everyone should try to maintain a healthy diet
and exercise regularly,” says Dr. Gerszten, who is committed to his own
daily 6 a.m. workouts. “But if you knew that you had a five-fold increased
likelihood of developing diabetes, wouldn’t that help motivate you to do
Above content provided by the CardioVascular Institute at Beth Israel
Deaconess Medical Center. For advice about your medical care, consult