| Risk Factors
PML is a rare progressive disease of the nervous system. It is caused by a viral infection of the cells that produce myelin.
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PML is caused by a specific papovavirus, known as JC virus. Most people get this infection in childhood and it produces no illness. It reactivates later in life in people who have suppressed immune systems.
The virus damages myelin, the material that wraps around nerves. This impairs nerve function.
PML is most common in people with supressed immune systems. Supressed immune systems may be the result of:
- Organ transplant
- Chronic steroid therapy
- Rare inherited immunodeficiencies
Certain medications, such as
natalizumab, a medication used to treat
Symptoms progress over weeks and may include:
- Vision problems
- Speech pronunciation problems
- Coordination loss
- Memory loss
- Weakness in limbs
- Behavioral changes
—a loss of language capability
- Sensory loss
Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:
Treatment focuses on strategies to improve the immune system. If you have HIV, your doctor will most likely prescribe antiretroviral medications to treat this condition. If PML has resulted from the drug natalizumab, your doctor will have you stop taking this drug and may recommend a
to remove the drug from your blood system.
There are no current guidelines to prevent exposure to the JC virus. If you have a suppressed immune system, get treatment to minimize your risk.