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Perilla frutescens

En Español (Spanish Version)

What is Perilla Used for Today? | Dosage | Safety Issues | References

What is Perilla Used for Today? | Dosage | Safety Issues

A member of the mint family, perilla is used in a variety of Asian foods to add both flavor and color. It is also grown ornamentally in gardens.

The stem of the plant is used in Chinese medicine for treatment of morning sickness. The leaves are said to be helpful for asthma, colds and flus, and other lung problems.

What is Perilla Used for Today?

Recently, extracts of perilla have undergone study as a treatment for allergic rhinitis (hay fever). Perilla contains high levels of the substance rosmarinic acid (also found in the herb rosemary and many other plants). Rosmarinic acid appears to have anti-inflammatory and anti-allergic actions. 1 In a 3-week double-blind, placebo-controlled study of 29 people with seasonal allergic rhinitis, participants were given one of three treatments: placebo, Perilla frutescens extract enriched to contain 50 mg of rosmarinic acid, or an extract enhanced to contain 200 mg of rosmarinic acid. 2 The results showed that both perilla products reduced symptoms to a greater extent than placebo.

Animal studies hint that perilla might also be useful for a different type of allergy: the severe, rapid reaction known as anaphylaxis, commonly associated with shellfish, peanut, and bee-sting allergies. 3,4

Very weak evidence suggests that rosmarinic acid and/or perilla may have anti-cancer effects 5,6 and might also have benefits for rheumatoid arthritis and other autoimmune diseases 7,8 as well as depression . 9

Dosage

A typical dosage of perilla should supply 50–200 mg of rosmarinic acid daily. Perilla also contains luteolin, a substance that may also have anti-allergic actions. 10,11 For this reason perilla products are often enriched with luteolin as well, typically providing 5–10 mg daily.

Safety Issues

In the small clinical trials and animal studies conducted thus far, use of perilla and/or rosmarinic acid has not been associated with significant adverse effects. Due to the wide use of perilla in Asian cooking, as well as the prevalence of rosmarinic acid in many spices, these substances are assumed to have a relatively high level of safety. However, comprehensive safety testing has not been reported. Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.

 

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