Possible Benefits and Risks
S-adenosylmethionine is a naturally occurring compound derived from the amino acid methionine and the energy molecule adenosine triphosphate (ATP). SAMe is widely used as a supplement for treatment of osteoarthritis and depression.
Preliminary evidence suggests that levodopa might deplete levels of SAMe in the body.
This suggests (but definitely does not prove) that individuals taking levodopa/carbidopa might benefit from SAMe supplements.
One short-term (30-day) double-blind study suggests that such combination treatment is safe and might help depression related to Parkinson's disease.
However, there are also concerns that SAMe could cause levodopa to be less effective over time.
The bottom line: If you are taking levodopa/carbidopa, consult your physician about whether you should take SAMe as well.