Potential Benefits and Risks
When the two are taken together, ipriflavone may increase estrogen's ability to protect bone.
This may allow you to use a lower dose of estrogen and still receive its beneficial effects.
However, there may be risks involved. Although ipriflavone itself probably does not affect tissues other than bone, some evidence suggests that when it is combined with estrogen, estrogen's effects on the uterus are increased.
This might mean that risk of uterine cancer would be elevated by the combination.
It should be possible to overcome this risk by taking
along with estrogen, which is standard medical practice. However, this finding does make one wonder whether ipriflavone-estrogen combinations raise the risk of breast cancer as well, an estrogen side effect that has no easy solution. At present, there is no available information on this important subject.