Complex regional pain syndrome (CRPS), previously known as reflex sympathetic dystrophy, is a chronic pain condition characterized by intense pain that is disproportionate to the initial injury that caused it. Other symptoms experienced by CRPS patients in the affected area include burning discomfort, changes in temperature and skin color, and extreme sensitivity to touch. CRPS may worsen over time and may spread to other parts of the body. Treatments aim to relieve painful symptoms, but no cure exists.
A previous study found that vitamin C reduced the risk of CRPS in people with wrist fractures. In a study published in the July 2007
Journal of Bone & Joint Surgery
, researchers set out to confirm those findings, and to determine the most effective vitamin C dose for CRPS prevention. They found that a daily dose of 500 milligrams of vitamin C taken for 50 days significantly reduced the risk of CRPS in people with fractured wrists, compared to placebo.
Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study.
J Bone Joint Surg Am