TUESDAY, Dec. 4 (HealthDay News) -- Scientists have long thought
that stress plays a role in epileptic seizures, and new evidence
suggests that epilepsy patients who believe this is the case
experience a different brain response when faced with a
Researchers from the University of Cincinnati performed
functional MRI brain scans during a stressful math exercise on 16
epilepsy patients who pegged stress as a factor in their seizure
control and seven patients who did not. While both groups performed
similarly on the test, those who perceived stress to have an impact
on their epilepsy showed greater brain activation than the others
during intimidating parts of the test.
"One of the things we often hear is that a lot of epilepsy
patients feel their seizures are affected by stress . . . but no
one had really looked at their [brain response] or other elements
of their physiological response," said study author Jane
Allendorfer, an instructor of neurology at the University of
Alabama at Birmingham. Allendorfer worked at University of
Cincinnati while the study was conducted.
"We were a bit surprised to see this difference," she added,
"but really excited to see it as well because this is something
that hadn't been done before."
The research was scheduled to be presented Monday at the annual
meeting of the American Epilepsy Society, in San Diego. Data
presented at scientific conferences often has not been
peer-reviewed or published and is considered preliminary.
A brain disorder producing repeated seizures, epilepsy affects
more than 2 million people in the United States, according to the
U.S. Centers for Disease Control and Prevention. An estimated 50
million to 65 million people are affected by the condition
For the new study, all participants were initially given simple
subtraction problems to solve and then a "stress task" during which
they performed difficult subtraction. Participants were given
positive feedback during the easier portion and negative feedback
during the difficult section regardless of how well they were
The brain activation observed on MRI among those who perceived
stress to impact their seizures was seen in several regions,
including the left temporal lobe, where their epilepsy originated.
No such brain activation was noted in the comparison group.
An epilepsy expert said the study results reflect what he hears
"Everyone who treats a lot of seizure patients knows that a good
proportion blame stress for any breakthrough seizures they're
having -- even when they're taking their medications, even when
they're not sleep-deprived," said Dr. Steven Pacia, director of the
Epilepsy Center and the division of neurology at Lenox Hill
Hospital in New York City. "This study is the first to truly show
there might be some activation issue in the brain that's different
in patients who report this problem. I think we all know that
telling patients to reduce their stress to reduce seizures is a
good thing to do."
Pacia and study author Allendorfer agreed that the research
needs to be replicated in larger groups of patients, which may
point to new ways of controlling or treating seizures.
"Eventually, if we can characterize the stress response in
patients . . . maybe this can be a way to target different kinds of
therapy to help reduce seizure frequency," Allendorfer said.
While the study found an association between stress response and
epileptic seizures, it did not prove a cause-and-effect
The U.S. National Library of Medicine has more about
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