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Sargramostim Injection

Brand Name(s): | Other Name(s): | WHY is this medicine prescribed? | HOW should this medicine be used? | What SIDE EFFECTS can this medicine cause? | What should I know about STORAGE and DISPOSAL of this medication? | What should I do in case of OVERDOSE? |

Brand Name(s):

  • Leukine®

Other Name(s):

  • GM-CSF

WHY is this medicine prescribed?

Your doctor has ordered sargramostim to help your bone marrow make new white blood cells. The drug will be either given subcutaneously (beneath your skin) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for 2 hours once a day for 14 to 21 days.

Sargramostim is a synthetic version of substances naturally produced by your body. It helps you to fight infections so you can receive your next chemotherapy cycle as scheduled.

Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how you respond to the medication.

What SPECIAL PRECAUTIONS should I follow?

Before administering sargramostim,

  • tell your doctor and pharmacist if you are allergic to any drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially cancer chemotherapy medications, dexamethasone (Decadron), lithium (Lithobid), prednisone, zidovudine (AZT, Retrovir), and vitamins.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking sargramostim, call your doctor.

HOW should this medicine be used?

Before you administer sargramostim, look at the solution closely. It should be clear and free of floating material. Observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the container leaks. Use a new solution, but show the damaged one to your health care provider.

It is important that you use your medication exactly as directed. Do not change your dosing schedule without talking to your health care provider. Patients with severe anemia often feel very tired and weak. Most patients start to feel better about 6 weeks after starting sargramostim. Do not stop your therapy on your own for any reason because your ability to avoid blood transfusions could be hampered.

What SIDE EFFECTS can this medicine cause?

The most common side effect during sargramostim therapy is mild bone pain, usually in the lower back or pelvis and lasting only a few days. Another common side effect is a flu-like syndrome with fever, fatigue, chills, and muscle aches. Your doctor may recommend that you take acetaminophen or other painkillers.

Tell your health care provider if any of these symptoms are severe or do not go away:
  • headache
  • diarrhea
  • skin rash or itching
  • weakness
  • dizziness or faintness
  • flushing of the face
If you experience any of the following symptoms, call your health care provider immediately:
  • fever
  • shortness of breath
  • sudden weight gain
  • swelling of the lower legs or feet

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site ] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?

  • Your health care provider probably will give you a several-day supply of sargramostim at a time. Your health care provider may give you directions on how to prepare each dose. Store the vials in the refrigerator.
  • Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
  • Avoid shaking the vial. Use a vial only once, and do not reenter a needle into a vial. Discard unused portions and outdated medication.
  • Do not allow sargramostim to freeze.

Store your medication only as directed. Make sure you understand what you need to store your medication properly.

Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

If you are receiving sargramostim in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
  • tenderness
  • warmth
  • irritation
  • drainage
  • redness
  • swelling
  • pain

AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: March 16, 2011.

 

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