Several hours before each dose of ibritumomab injection, a medication called rituximab (Rituxan) is given. Some patients have had serious or life-threatening allergic reactions while they received rituximab or shortly after they received rituximab. These reactions have occurred most often with the first dose of rituximab. Some patients have died within 24 hours after receiving rituximab. Tell your doctor if you are allergic to rituximab or medications made from murine (mouse) proteins, or if you are not sure if a medication you are allergic to is made from murine proteins. Also tell your doctor if you have ever been treated with a medication made from murine proteins. If so, you may be more likely to have an allergic reaction to rituximab. Your doctor will order tests to see if you are likely to have an allergic reaction to rituximab.
Your doctor will give you medication before you receive rituximab to help prevent reactions to rituximab. If you experience a reaction to rituximab, your doctor may stop giving you the medication for a time or may give it to you more slowly. If the reaction is serious, your doctor will stop the rituximab infusion and will not continue your treatment with ibritumomab injection. Tell your doctor right away if you experience any of the following symptoms during or shortly after your treatment with rituximab: cough; difficulty breathing or swallowing; tightening of the throat; hives; itching; swelling of the eyes, face, lips, tongue, mouth, or throat; pain in the chest, jaw, arm, back, or neck; confusion; loss of consciousness; fast heartbeat; sweating; pale skin; fast breathing; decreased urination; or cold hands and feet.
Treatment with rituximab and ibritumomab injection may cause a severe decrease in the number of blood cells in your body. This decrease may happen 7 to 9 weeks after your treatment and may last for 12 weeks or longer. This decrease may cause serious or life-threatening infections or bleeding. Your doctor will not give you ibritumomab injection if your blood cells have been severely affected by cancer, if you have had a bone marrow transplant, if you have been unable to produce enough stem cells (cells found in the bone marrow that can mature to form any type of blood cell) to have a bone marrow transplant, or if you already have a low number of blood cells. Tell your doctor if you are taking any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve); and clopidogrel (Plavix). If you have any of the following symptoms, call your doctor right away: pale skin; weakness; unusual bruising or bleeding; purple spots or patches on the skin; black or bloody stools; vomit that is bloody or looks like coffee grounds; diarrhea; or sore throat, fever, chills, cough, or other signs of infection.
Treatment with rituximab and ibritumomab injection may cause serious or fatal skin reactions. These reactions may occur as soon as a few days after treatment or as long as 4 months after treatment. Tell your doctor right away if you develop blisters on your skin or on the inside of your mouth or nose, a rash, or peeling of the skin. Your doctor will not give you any more ibritumomab injection if you develop these symptoms.
After you receive your first dose of ibritumomab injection, your doctor will order imaging scans (tests that show a picture of all or part of the inside of the body) to see how the medication has spread through your body. If the medication has not spread through your body as expected, you will not receive your second dose of ibritumomab injection.
Keep all appointments with your doctor and the laboratory.Your doctor will order certain tests during your treatment and for up to 3 months after your treatment to check your body's response to ibritumomab injection.
Talk to your doctor about the risks of receiving ibritumomab injection.
What OTHER INFORMATION should I know?
Ask your doctor or pharmacist any questions you have about ibritumomab injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: March 1, 2009.