HOW should this medicine be used?
Insulin aspart comes as a solution (liquid) and a suspension (liquid with particles that will settle on standing) to inject subcutaneously (under the skin). Insulin aspart solution (NovoLog) is usually injected 5–10 minutes before eating a meal. If you are using insulin aspart suspension (NovoLog Mix 70/30) to treat type 1 diabetes, it is usually injected within 15 minutes before a meal. If you are using insulin aspart suspension to treat type 2 diabetes, it is usually injected within 15 minutes before or after a meal. Your doctor will tell you how many times you should inject insulin aspart each day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use insulin aspart exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Insulin aspart solution (NovoLog) may also be injected intravenously (into a vein) by a doctor or nurse in a health care setting. A doctor or nurse will carefully monitor you for side effects.
Never use insulin aspart when you have symptoms of hypoglycemia (low blood sugar) or if you have checked your blood sugar and found it to be low. Do not inject insulin into a skin area that is red, swollen, itchy, or thickened.
Insulin aspart controls diabetes but does not cure it. Continue to use insulin aspart even if you feel well. Do not stop using insulin aspart without talking to your doctor. Do not switch to another brand or type of insulin or change the dose of any type of insulin you are using without talking to your doctor. Always check the insulin label to make sure you received the right type of insulin from the pharmacy.
Insulin aspart comes in vials, cartridges that contain medication and are to be placed in dosing pens, and dosing pens that contain cartridges of medication. Be sure you know what type of container your insulin aspart comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication.
If your insulin aspart comes in vials, you will need to use syringes to inject your dose. Ask your doctor or pharmacist to show you how to inject insulin aspart using a syringe. Ask your doctor or pharmacist if you have questions about the type of syringe you should use.
If your insulin aspart comes in cartridges, you will need to buy an insulin pen separately. Check the manufacturer's information for the patient to see what type of pen is right for the cartridge size you are using. Carefully read the instructions that come with your pen, and ask your doctor or pharmacist to show you how to use it. Ask your doctor or pharmacist if you have questions about the type of pen you should use.
If your insulin aspart comes in pens, be sure to read and understand the manufacturer's instructions. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully, and always prime the pen before use.
Never reuse needles or syringes and never share needles, syringes, cartridges, or pens. If you are using an insulin pen, always remove the needle right after you inject your dose. Throw away needles and syringes in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container.
Your doctor may tell you to mix your insulin aspart solution with another type of insulin (NPH insulin) in the same syringe. Your doctor will tell you exactly how to do this. Always draw insulin aspart into the syringe first, always use the same brand of syringe, and always inject the insulin immediately after mixing. Insulin aspart solution should not be mixed with insulin preparations other than NPH insulin. Insulin aspart suspension should not be mixed with any other insulin preparations.
Your doctor may tell you to dilute insulin aspart before injection to allow easier measurement of your dose. Your doctor will tell you exactly how to do this.
You can inject your insulin aspart in your thighs, stomach, upper arms, or buttocks. Never inject insulin aspart into a vein or muscle. Change (rotate) the injection site within the chosen area with each dose; try to avoid injecting the same site more often than once every 1–2 weeks.
Always look at your insulin aspart before you inject it. If you are using insulin aspart solution, the insulin should be clear and colorless. Do not use this type of insulin aspart if it is colored, cloudy, thickened, or contains solid particles. If you are using insulin aspart suspension, the insulin should appear cloudy or milky after you mix it. Do not use this type of insulin if there are clumps in the liquid or if there are solid white particles sticking to the bottom or walls of the bottle. Do not use any type of insulin after the expiration date printed on the bottle has passed.
Insulin aspart suspension must be rolled gently between your hands to mix before use. Do not shake insulin aspart suspension. Ask your doctor or pharmacist if the type of insulin you are using should be mixed and how you should mix it if necessary.
Insulin aspart solution also can be used with an external insulin pump. Before using insulin aspart in a pump system, read the pump label to make sure the pump can be used for continuous delivery of fast-acting insulin. Read the pump manual for recommended reservoir and tubing sets, and ask your doctor or pharmacist to show you how to use the insulin pump. Do not dilute insulin aspart or mix it with any other type of insulin when using it in an external insulin pump. When using insulin aspart with an external insulin pump, replace the insulin in the reservoir at least every 6 days, and change the infusion set and infusion set insertion site at least every 3 days. If the infusion site is red, itchy, or thickened, tell your doctor and use a different infusion site.
When using insulin apart solution in an external insulin pump, high blood sugar may occur quickly if the pump stops working properly or if the insulin in the pump reservoir is exposed to direct sunlight or temperatures greater than 98.6°F (37°C). High blood sugar may also occur if the tubing leaks or becomes blocked, disconnected, or kinks. If the problem cannot be found quickly and corrected, call your doctor right away. You may need to temporarily use insulin by subcutaneous injection (using syringes or an insulin pen). Make sure you have back-up insulin and any necessary supplies on hand, and ask your doctor or pharmacist to show you how to use them.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in and out of reach of children. Store unopened insulin aspart vials, cartridges, and pens in the refrigerator but do not freeze them. Unopened refrigerated insulin aspart can be stored until the date shown on the company's label.
If no refrigerator is available (for example, when on vacation), store the vials, cartridges, or pens at room temperature and away from direct sunlight and extreme heat. Unrefrigerated vials, cartridges, and pens can be used within 28 days or after that time they must be thrown away. Unrefrigerated pens containing NovoLog Mix 70/30 can be used within 14 days or after that time they must be thrown away. Opened vials can be stored for 28 days at room temperature or in the refrigerator. If your doctor tells you to dilute your insulin aspart, the vial of diluted medication can be stored for up to 28 days in the refrigerator or at room temperature. Opened cartridges and pens may be stored at room temperature for up to 28 days; do not refrigerate them. Opened pens containing NovoLog Mix 70/30 may be stored at room temperature for up to 14 days; do not refrigerate them. Throw away any insulin aspart that has been exposed to extreme heat or cold.
Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.