Possible Harmful Interaction
The herb St. John's wort
is primarily used to treat mild to moderate depression.
St. John's wort has the potential to accelerate the body's normal breakdown of certain drugs
including cyclosporine, resulting in lower blood levels of these drugs.
This interaction appears to have occurred in two heart transplant patients taking cyclosporine, leading to heart transplant rejection.
These individuals had been doing well after transplantation while taking standard immunosuppressive therapy that included cyclosporine. After starting St. John's wort for depression, however, they began experiencing problems and their blood levels of cyclosporine were found to have dipped below the therapeutic range. After St. John's wort was discontinued, cyclosporine levels returned to normal and no further episodes of rejection occurred.
Numerous cases of transplant rejection episodes involving the heart, kidney, and liver have also been reported in people using the herb.
Based on this evidence, if you are taking cyclosporine, you should not take St. John's wort.