Possible Harmful Interaction
The body uses the natural substance 5-hydroxytryptophan (5-HTP) to manufacture serotonin, and supplemental forms have been used for treating depression and
S-adenosylmethionine (SAMe) is a naturally occurring compound derived from the amino acid methionine and the energy molecule adenosine triphosphate (ATP). SAMe is widely used as a supplement for treating
Based on one case report and current thinking about how they work, SAMe and 5-HTP should not be taken with SSRIs, as they might increase the risk of serotonin syndrome.
This syndrome is a toxic reaction brought on by too much serotonin activity. The condition requires immediate medical attention, with symptoms including anxiety, restlessness, confusion, weakness, tremor, muscle twitching or spasm, high fever, profuse sweating, and rapid heartbeat.
The report describes a case of apparent serotonin syndrome in an individual taking SAMe with clomipramine, a
that increases serotonin activity.
Although SAMe is not currently known to affect serotonin, it does appear to have antidepressant effects and may in some way increase serotonin activity.
Because SSRIs increase serotonin activity even more than clomipramine, a similar problem might occur if you combine SAMe with an SSRI.
The supplement 5-HTP is used by the body to manufacture serotonin, so it could also increase the risk of serotonin syndrome when combined with an SSRI.