Genes linked to organ rejection
Researchers have identified a distinct pattern of gene expression in the largest reported group of kidney transplant recipients who have not rejected the transplant kidneys even though they stopped taking anti-rejection drugs.
This finding may help identify other transplant recipients who could safely reduce or end use of immunosuppressive therapy. In 2008, more than 80,000 people in the United States were living with a kidney transplant. The report appears online in the Journal of Clinical Investigation.
The findings come from the Immune Tolerance Network (ITN), an international research consortium supported by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases, of the National Institutes of Health, and the Juvenile Diabetes Research Foundation International. The research team included Beth Israel Deaconess Medical Center (BIDMC) investigator Laurence Turka, MD, together with Kenneth Newell, MD, PhD, of Emory University in Atlanta; and Vicki Seyfert-Margolis, PhD, of the U.S. Food and Drug Administration (FDA).
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