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Pier Paolo Pandolfi Lab

Pier Paolo Pandolfi, M.D., Ph.D., holds joint appointments in our department and the Department of Medicine. He is also the director of the new Cancer Genetics Center at BIDMC as well as a Professor of Medicine and Pathology at Harvard Medical School.

Selected Recent Publications

Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D,Cordon-Cardo C, Pandolfi PP. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human  cancer. Cancer Res. 2007 Aug 1;67(15):7106-12.

Cheng K, Grisendi S, Clohessy JG, Majid S, Bernardi R, Sportoletti P, Pandolfi PP. The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.Oncogene. 2007 Jun 4; [Epub ahead of print]

Salmena L, Pandolfi PP. Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation. Nat Rev Cancer. 2007 Jun;7(6):409-13. Epub 2007 May 17. Review.

Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi  PP. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.  Science. 2007 May 11;316(5826):860-6.

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, PavletichNP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 2007 Jan 12;128(1):141-56.

Shen TH, Lin HK, Scaglioni PP, Yung TM, Pandolfi PP. The mechanisms of PML-nuclear body formation.  Mol Cell. 2006 Nov 3;24(3):331-9.

Bergmann S, Pandolfi PP. Giving blood: a new role for CD40 in tumorigenesis.J Exp Med. 2006 Oct 30;203(11):2409-12. Epub 2006 Oct 16.

Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J,Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.  PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature. 2006 Aug 17;442(7104):779-85.

 

Contact Information

Pier Paolo Pandolfi, MD, PhD
Division of Genetics
Beth Israel Deaconess Medical Center
CLS Building, Room 401
330 Brookline Avenue
Boston, MA 02215
617-735-2121
617-735-2120 
ppandolf@bidmc.harvard.edu