Katie Bentley Lab
Katie Bentley earned a PhD in Computer Science from University College London in 2006 investigating morphological plasticity in biological and robotic systems after gaining an interdisciplinary Masters from the University of Sussex in 2002 in evolutionary and adaptive systems. She was awarded a Cancer Research UK postdoctoral fellowship to develop vascular computational models in Paul Bates Biomolecular Modelling Laboratory at the CR UK, London Research Institute in 2006. She was then awarded a Leducq Fondation transatlantic network grant postdoctoral fellowship to work within Holger Gerhardt's Vascular Biology Laboratory and alongside international collaborators in 2009. Katie Bentley was appointed group leader of the Computational Biology Laboratory in the Experimental Pathology Department BIDMC and became a member of the CVBR in 2013.
Computational Modeling of the Vasculature Basic Research: My laboratory develops novel computational approaches to build understanding of the underlying mechanisms of vascular morphogenesis, in normal and pathological conditions. The lab principally integrates computer simulation, and design of new automated image analysis algorithms, with in vitro and in vivo biological experimentation to understand the spatial and temporal aspects of endothelial adaptive behavior uncovering environmental "switches" that lead to abnormalities in disease, with the direct aim of providing new therapeutic avenues. The laboratory also draws on studies of morphogenesis and computational development from outside the vascular field in order to draw fresh inspiration for uncovering novel vascular mechanisms from other systems (eg. The highly environmentally plastic morphogenesis behaviors exhibited by diatoms) and also to develop much needed ground work in computational and theoretical biology infrastructure and resources for integrated projects, e.g. development of image analysis software to aid quantification of timelapse data in vascular confocal microscopy. In particular the lab focuses on the interplay of Notch signaling with the VEGF family of receptors, the cytoskeleton and cell migration/communication behaviors. The role of Notch oscillations in vascular pathology and cell rearrangement mechanisms.