Ovarian Aging
Richard H. Reindollar, MD, Associate Professor, Harvard Medical School
Director, Reproductive Endocrinology
Reproductive Endocrinology Fellow Director
Dr. Reindollar earned his M.D. degree from the Bowman Gray School of Medicine in Winston Salem, NC. He completed his residency in obstetrics and gynecology at York Hospital, York, PA, and completed a fellowship in reproductive endocrinology and genetics at Medical College of Georgia, Augusta, GA.. Dr. Reindollar has been awarded numerous citations for excellence in teaching and is the past-president of the Society of Reproductive Endocrinologists, and the Boston Fertility Society. He is also a founding fellow of the American College of Medical Genetics, a past-president of the North American Society for Pediatric and Adolescent Gynecology, and a member of many other professional organizations. He has published a great number of articles in professional medical journals, as well as abstracts and invited book chapters, and has lectured extensively at postgraduate courses and seminars.
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Research Project |
Short Description |
Sources of Outside Funding |
Amount of Funding |
|
Optimal Infertility Therapy RCT |
Women 40 and Older Randomized controlled trial to identify the most effective infertility treatment for couples from the 40th birthday of the female partner to the 43rd birthday. Parameters followed include cost effectiveness, success rates, adverse outcomes. |
NIH |
$2.7 million/5 years |
Conventional Infertility Therapy vs. A Fast Track to IVF |
Randomized controlled trial of a standard infertility paradigm compared to a fast track to IVF for couples up to the female partner's 40th birthday. Parameters followed include cost effectiveness, success rates, adverse outcomes. |
NIH |
$2.7 million/5years |
Molecular Basis of Congenital Absence of the Uterus and Vagina (CAUV) |
Use of a number of molecular strategies to identify molecular basis of CAUV and determine the genes involved in development of the mullerian system. Research is designed to identify both germline and somatic cell mutations. |
Industry |
$10,000 (Organon)
$2,000 (Ferring) |
| Gene expression profiles of human ovarian granulosa cells in young and aged women undergoing in vitro fertilization |
The purpose of this study is to identify and describe differential gene expression profiles in the granulosa cells of women undergoing IVF who are of varying age and have variable responses to ovulation induction. |
Industry |
$10,000 (Serono) |
| Development of stem cell lines from donated cryopreserved embryos |
A collaborative study between Boston IVF and Department of Biology, Harvard University, to develop stem cell lines from donated cryopreserved embryos. |
Howard Hughes Foundation
Prof. Doug Melton,
Harvard University |
$100,000 a year for 6
years. |
A Randomized Quality of Life, Efficacy, Safety, and Tolerability
(QUEST) |
Study of Bravelle + Repronex, vs Gonal-F in Controlled Ovarian Hyperstimulation for In Vitro Fertilzation. Primary Investigator- Alan S. Penzias, M.D. |
Ferring Pharmaceuticals |
|
Cryopreservation of Human Oocytes followed by Post-Thaw Evaluation
of Survival. |
A Collaborative study between Boston IVF, ViaCell Inc,
and Gamete Technology Inc.
Investigators R. Douglas Powers PhD., Michael Alper M.D. |
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Selected Publications
Resendes BL, Sohn SH, Stelling JR, Tineo R, Davis AJ, Gray MR, Reindollar RH. The role for anti-müllerian hormone in congenital absence of the uterus and vagina. Am J of Med Gen 2001;98(2)129-36.
Layman LC, McDonough PG, Cohen DP, Maddox M, Thos SPT, Reindollar RH. Familial gonadotropin releasing hormone resistance and hypogonadotropic hypogonadism in a family with multiple affected individuals. Fertil Steril June 2001; 75(6):1148-1155.
Diamond MP, Bieber E and the Sepracoat and Seprafilm Study Groups. Serum Electrolytes, Chemistries and Blood Cell Counts After Gynecologic Surgery in Healthy Women. J Gynecologic Techniques.
Klipstein S, Reindollar RH, Regan M Alper MM. Gender Bias in the Disposition of Frozen Embryos. Fertil Steril December 2001; 76(6):1181-1184.
Reindollar R, Koulton W, Parsons A, Rosen A, Siddhanti, Pouffe L. Effects of oral raloxifene on serum estradiol levels and other markers of estrogenicity. Fertil Steril September 2002; 78(3)469-472.
Stelling JR, Chapman ET, Frankfurter D, Harris DH, Oskowitz SP, Reindollar R. Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle. Fertil Steril April 2003; 79(4):881-885.
Timmreck L, Gray M, Handelin B, Allito B, Rohlfs E, Davis AJ, Gidwani G, Reindollar RH. Analysis of cystic fibrosis transmembrane conductance regulator gene mutations in patients with congenital Absence of the Uterus and Vagina. Amer J Med Gen July 2003; 120A(1):72-76.
Klipstein S, Bhagavath B, Topipat C, Sasur L, Reindollar RH, Gray MR, The N314D polymorphism of the GALT gene is not associated with congenital absence of the uterus and vagina (CAUV). .Molec. Human Reprod. 2003;9(3):171-74.
Karnis MF, Zimon AE, Lalwani SI, Timmreck LS, Klipstein S, Reindollar RH. The Risk of Death in Pregnancy Achieved through Oocyte Donation in Patients with Turner Syndrome: A National Survey Fertil Steril, September 2003;80(3):498-501.
Lalwani S, Timmreck L, Friedman R, Penzias A, Alper M, Reindollar RH. Variations in individual physician success rates within an in vitro fertilization program maybe due to patient demographics. Fertil Steril, 2003 (In press).
Klipstein S, Alper M, Regan MM, Reindollar RH, Initiation of a GnRH antagonist in IVF cycles in which the lead follicle is greater than 14mm. Fertil. Steril 2003. (In press).
