beth israel deaconess medical center a harvard medical school teaching hospital

To find a doctor, call 800-667-5356 or click below:

Find a Doctor

Request an Appointment

left banner
right banner
Smaller Larger

Publications

Scammell, TE, Elmquist, JK, Griffin, JD, Saper, CB. Ventromedial preoptic PGE2 activates fever-producing autonomic pathways. Journal of Neuroscience 1996; 16:6246-6254.

Scammell, TE, Gerashchenko, D, Urade, Y, Onoe, H, Saper, C, Hayaishi, O. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proceedings of the National Academy of Sciences, 1998; 95:7754-7759.

Chemelli, RM, Willie, JT, Sinton, CM, Elmquist, JK, Scammell, T, Lee, C, Richardson, JA, Williams, SC, Xiong, Y, Kisanuki, Y, Fitch, TE, Nakazato, M, Hammer, RE, Saper, CB, and Yanagisawa, M, Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell, 1999. 98(4): p. 437-51.

Scammell, TE, Estabrooke, IV, McCarthy, MT, Chemelli, R, Yanagisawa, M, Miller, MS, and Saper, CB. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. Journal of Neuroscience, 2000, 20:8620-8.

Estabrooke, IV, McCarthy, MT, Ko, E, Chou, T, Chemelli, R, Yanagisawa, M, Saper, CB, Scammell, TE. Orexin neuron activity varies with behavioral State. Journal of Neuroscience 2001, 21: 1656-1662.

Chou, TC, Lee, CE, Lu, J, Elmquist, JK, Hara, J, Willie, JT, Beuckmann, CT, Chemelli, RM, Sakurai, T, Yanagisawa, M, Saper, CB, Scammell, TE. Orexin (hypocretin) neurons contain dynorphin. Journal of Neuroscience, 2001, 21:RC168(1-6).

Kramer, A, Yang, F-C, Snodgrass, P, Li, X, Scammell, TE, Davis, FC, Weitz, CJ. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science, 2001, 294:2511-5.

Scammell, TE. The neurobiology, diagnosis, and treatment of narcolepsy. Annals of Neurology, 2003, 53:154-166.

Scammell, TE, Thompson, MA, Saper, CB, and Greene, R. Focal Deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. Journal of Neuroscience, 2003, 23:5762-70.

Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, and Scammell TE. Behavioral State Instability in Orexin Knock-Out Mice. Journal of Neuroscience 2004, 24:6291-6300.

España, RA and Scammell, TE. Sleep Neurobiology for the Clinician. Sleep 2004, 27:811-820.

Anderson, MP, Mochizuki, T, Jinghui Xie, J, Fischler, W, Manger, JP, Talley, EM, Scammell, TE, and Tonegawa, S. Thalamic Cav3.1 T-type Ca2+ Channel Plays a Crucial Role in Stabilizing Sleep, Proceedings of the National Academy of Sciences 2005, 102:1743-1748.

Crocker, A, España, RA, Papadopoulou, M, Saper, CB, Faraco, J, Sakurai, T, Honda, M, Mignot, E, and Scammell, TE. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology. 2005, 65:1184-8.

Yoshida, K, McCormack, S, España, RA, Crocker, A, Scammell, TE. Afferents to the orexin neurons of the rat brain. J Comp Neurol. 2005 494:845-861.

Saper, CB, Scammell, TE, and Lu, J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005, 437:1257-63.

Mochizuki T, Klerman EB, Sakurai T, Scammell TE. Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol. 2006, 291:R533-40.

España, R, McCormack, S, Mochizuki, T, and Scammell, TE. Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep, 2007, 30:1417-1425.

Diniz Behn, C, Kopell, N, Brown, EN, Mochizuki, T, Scammell, TE. Delayed orexin signaling consolidates wake and sleep: physiology and modeling. J Neurophysiol, 2008, 99:3090-103.

Scammell, TE, Willie, JT, Guilleminault, G, Siegel, JM. A consensus definition of cataplexy in mouse models of narcolepsy. Sleep, 2009, 32:111-116.

Clark, EL, Baumann, CR, Cano, G, Scammell, TE, Mochizuki, T. Feeding-elicited cataplexy in orexin knockout mice. Neuroscience, 2009, 161:970-977.

Kantor, S, Mochizuki, T, Janisiewicz, AM, Clark, E, Nishino, S, Scammell, TE. Orexin neurons are necessary for the circadian control of REM sleep. 2009, 32:1127-1134.

Baumann, CR, Bassetti, CL, Valko, PO, Haybaeck, J, Keller, M, Clark, E, Stocker, R, Tolnay, M, Scammell, TE. Loss of hypocretin (orexin) neurons with traumatic brain injury, Annals of Neurology, 2009, 66:555-559.

Diniz Behn, CG, Klerman, EB, Mochizuki, T, Lin, S-C, and Scammell, TE. Abnormal sleep/wake dynamics in orexin knockout mice. Sleep, 2010, 33:297-306.

Saper, CB, Fuller, PM, Pedersen, NP, Lu, J, Scammell, TE. Sleep State Switching. Neuron, 68:1023-1042, 2010.

Scammell, TE, Matheson, JK, Honda,, M, Thannickal,, TC, and Siegel, JM. Coexistence of narcolepsy and Alzheimer's disease. Neurobiology of Aging, 2011, in press.

Scott, MM, Marcus, JN, Pettersen, A, Birnbaum, S, Mochizuki, T, Scammell, TE, Nestler, EJ, Elmquist, JK, Lutter, M. Orexin 1 and 2 receptor signaling differentially regulates depression-like behaviors. Behavioral Brain Research, 2011, in press.

Mochizuki, T, Arrigoni, E, Marcus, JN, Clark, EL, Yamamoto, M, Honer, M, Borroni, E, Lowell, BB, Elmquist, JK, and Scammell, TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proceedings of the National Academy of Sciences, 2011, 108:4471-6.

Scammell, TE, Winrow, CJ. Orexin Receptors: Pharmacology and Therapeutic Opportunities. Annual Review of Pharm and Tox. 51:243-66, 2011.

España, R, and Scammell, TE. Sleep Neurobiology from a Clinical Perspective. Sleep 2011, in press.