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Respiratory and Anesthesia Translational Group

Research Interests

City of Boston

The Respiratory and Anesthesia Translational Group (RAT) comprises a group of investigators with the common interest in improving anesthesia safety and efficacy. We conduct research at both the preclinical and clinical levels on the fundamental neurological mechanisms of anesthesia and breathing. Our investigators, located at the Beth Israel Deaconess Medical Center (BIDMC), Massachusetts General Hospital (MGH), and Brigham and Women's Hospital (BWH), have performed studies on topics such as safety of reversal of neuromuscular blockade, interactions of anesthetics with endogenous sleep/wake systems and comparisons of effects of different anesthetic agents on upper airway muscles and breathing.

Ongoing work addresses fundamental mechanisms of action of anesthetics, respiratory arousal following airway obstruction, and safety of hypnotic agents in airway patency.

Group members include (alphabetically)

Principal Investigaors:
Nancy L. Chamberlin (BIDMC)
Matthias Eikermann (MGH)
Atul Malhotra (BWH)
Carl Roscow (MGH)

Mark Henry

Past trainees:
Philipp Fassbender
Sebastian Zaremba
Martina Grosse-Sundrup
Lisa Kaplin

Selected Recent Publications

Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats.
Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, and Chamberlin NL. Anesthesiology 2009, in press

Herbstreit F, Peters J, Eikermann M.
Impaired upper airway integrity by residual neuromuscular blockade: Increased airway collapsibility and blunted genioglossus muscle activity in response to negative pharyngeal pressure. Anesthesiology 2009, in press.

Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL.
Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.
Br J Anaesth. 2008 Sep;101(3):344-9. Epub 2008 Jun 16.

Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL
Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing.
Anesthesiology. 2008 May;108(5):897-906.

Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL.
Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function.
Anesthesiology. 2007 Oct;107(4):621-9.

Eikermann M, Chamberlin NL, Gerber H, Malhotra A.
Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily.
Crit Care Med. 2007 Jun;35(6):1634-5.

Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A.
The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5.

Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A.
Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol. 2007 Mar 1;579(Pt 2):515-26. Epub 2006 Dec 21.