beth israel deaconess medical center a harvard medical school teaching hospital

To find a doctor, call 800-667-5356 or click below:

Find a Doctor

Request an Appointment

left banner
right banner
Smaller Larger

Recent Discoveries

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Zhou YD, Lee S, Jin Z, Wright M, Smith SE, Anderson MP. Nat Med. 2009 15(10):1208-14.




( a) Representative traces showing PPF of evoked MPP-GC postsynaptic currents, a measure of release probability, increases between P17 and P23 in control (WT) mice. ( b) Western blots showing expression of LGI1 and its receptor, ADAM22, between P13 and P25. ( c) Representative traces showing PPF in mature mLGI1 and mature LGI1 OE mice relative to control mice. ( d) Western blot showing expression of 64-kDa LGI1 in LGI1 OE mice and expression of 23-kDa mutant LGI1, marked by an arrow on densitometry traces, in mLGI1 mice. ( e) Quantification of 64-kDa LGI1 protein density (normalized to beta-actin) in WT, LGI1 OE and mLGI1 mice ( n = 7). ( f) Paired-pulse ratio in mature mice after treatment with the Kv1 channel blocker alpha-dendrotoxin (DTX). ( g) Quantification of paired-pulse ratio in WT, mLGI1 and LGI1 OE mice ( n = 4 to 25). * P < 0.05; ** P < 0.01; *** P < 0.001. Data represent means +-s.e.m.