beth israel deaconess medical center a harvard medical school teaching hospital

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Dr. Terry Strom

The Beth Israel Deaconess Medical Center has recently now organized a multi-disciplinary Transplant Center. Dr. Terry Strom and Dr. Doug Hanto are co-directors with Dr. Strom serving as the Scientific Director. The Transplant Research Center is home to 60 full-time scientists who specialize in immunobiology and cytoprotection of transplanted tissue. Terry Strom and Cox Terhorst , internationally recognized authorities in molecular immunology at the Beth Israel Deaconess Medical Center and Harvard Medical School, are co-directors of the Department of Medicine's Division of Immunology. Strom's laboratory has focused his efforts upon molecular aspects of T-cell biology, transplantation rejection and tolerance. The ultimate goal of this laboratory is to use molecular technology to 1) understand the mechanism of graft rejection, and, create tolerance, and 2) to develop new therapeutics and molecular diagnostic techniques to support the goal of creating a immune tolerance. A new protein designed and developed in this lab is soon to enter clinical trials as a monotherapy in industry sponsored trials while a two protein regimen developed and designed in his laboratory will be tested in NIH sponsored trials. In both cases certain autoimmune diseases as well as transplantation will be the clinical targets. In preclinical models the biology of T cell regulation, a crucial component of immune tolerance, is being studied at the whole animal, cellular and molecular levels. Dr. Strom's lab also has developed molecular profiling methods (proteomic and transcriptional profiling) to assess the quality of the organ transplant in the OR and to follow the host immune response post-transplantation. These methods are now being tested for clinical applicability in NIH sponsored trials.

The laboratory is outfitted with highly sophisticated equipment to undertake molecular and cellular immunology studies. In fact, Dr. Strom's laboratory houses the instrumentation for BIDMC 's genomic center. This instrumentation includes Affymetrix GeneChip technology and robotic real time PCR. The laboratory is readily accessible to the CORE facilities that provide a vehicle to create transgenic mice, such as gene knockout mice, DNA, and computing at the Beth Israel Deaconess Medical Center as well as close collaborative arrangements with a variety of scientists at Harvard Medical School.

The research fellow's activities include weekly laboratory meetings, weekly immunology journal club, weekly Harvard Medical School immunology seminars, weekly Beth Israel transplant seminars, and monthly Juvenile Diabetes Research Foundation- Harvard Islet Transplant Center scientific meetings.

A lively program of seminars within Beth Israel Deaconess Medical Center's Division of Immunology is available to the candidate. At least 90% of the applicant's time will be devoted to research. A two-week vacation leave is allowed and participation in select scientific meetings is encouraged.