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Seth Alper Laboratory

Seth Alper, MD, PhD
Professor of Medicine, Harvard Medical School

The Alper lab investigates the molecular pathophysiology, disease genetics, and physiology of plasma membrane ion transporters and channels in renal, gastrointestinal, and other epithelial cells and in red blood cells. The lab’s ongoing functional and genetic studies involve transporters of the SLC4, SLC26, and SLC12 gene families, and ion channels KCNN4, polycystins, ABCB6, and CFTR. 

A second area of interest is the ion transport pathophysiology of chronic renal disease, including ADPKD, APOL1 kidney disease (with Martin Pollak and David Friedman), MUC1/ADTKD kidney disease (with Johannes Schlondorff), and peritoneal fibrosis associated with peritoneal dialysis.

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Contact Information

Division of Nephrology
Beth Israel Deaconess Medical Center
East Campus/Research North
99 Brookline Ave
Boston, MA 02215