Mark Zeidel Laboratory
Mark L. Zeidel, MD
Herrman L. Blumgart Professor of Medicine, Harvard Medical School
Chairman, Department of Medicine
Dr. Zeidel's research focuses on mechanisms of water and small molecule flow across biological membranes and on mechanisms of epithelial injury. The first measurements of intracellular pH in renal cells, the discovery that atrial natriuretic peptide and related peptides (such as brain natriuretic peptide) function by blocking renal sodium reabsorption in collecting duct cells, the reconstitution and biophysical definition of the function of aquaporin water channels and the molecular definition of how membranes can be impermeable to gases and water are a few of the major research findings in his laboratories. Dr. Zeidel's research has been recognized by the American Physiological Society, the American Society for Clinical Investigation and the Association of American Physicians. His research has received continuous funding by the NIH for over 20 years.