beth israel deaconess medical center a harvard medical school teaching hospital

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Dr. David Friedman

Areas of Interest

Renal microvascular disease, particularly diabetic nephropathy

Renovascular autoregulation

Venous arterialization, with applications to arteriovenous fistula maturation and stenosis

The common theme linking these three topics is an interest in the puringeric signaling system. This system is composed of purinergic receptors (P2X and P2Y), adenosine receptors, and the ectonucleotidases that regulate extracellular purine levels. Purinergic signaling is important in many cellular processes including inflammation, thrombosis, apoptosis, cell growth, and blood vessel tone. The lab use knock-out and transgenic mice for various components of this system to investigate their roles in normal physiology and disease models. In addition, along with collaborators at the Broad Institute and Wake Forest School of Medicine, they test human variation in these genes to study their role in human disease


Dr. David Friedman