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Select Publications from the Kalluri Lab

Zeisberg M, Kalluri. R. Reversal of Experimental Renal Fibrosis by BMP7-Novel Insights into Therapeutic Strategies for CKD. Pediatric Nephrology, 2008 (in Press).

LeBleu V, Sugimoto H, Miller C, Gattone V, Kalluri R. B- and T-Lymphocytes are Dispensable for the Emergence of Glomerulonephritis but Required for the Pathogenesis of Renal Interstitial Fibrosis. Lab. Invest. 2008 Mar; 88(3): 284-92.

Xie L, Palmsten K, McDonald BM, Potenta S, Vong S, Sugimoto H, Kalluri R. Basement Membrane Derived Fibulin-1 and Fibulin-5 Function as Angiogenesis Inhibitors Inhibit Tumor Growth. Exp. Biol. Med. 2008 Feb; 233(2): 155-62.

Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid
H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008 Jan; 14(1):55-63.

Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, LeBleu V, Gattone V, Kalluri R. Integrin β Mediated Matrix Assembly and Signaling is Critical for the Normal Development and Function of the Kidney Glomerulus. Dev Bio. 2008 Jan 15;313(2):584-93.

Tanjore H, Zeisberg E, Naini-Gerami B and Kalluri R. Beta1 Integrin Expression on Endothelial Cells is Required for Angiogenesis but Dispensable for Vasculogenesis. Dev. Dyn. 2008 Jan;237(1):75-82.

Zeisberg E, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts. Cancer Res. 2007 Nov 1;67(21):10123-8. Mundel T, Kalluri R. Type IV collagen-derived Angiogenesis Inhibitors. Microvascular Research. 2007 September - November;74(2-3):85-89. 

Zeisberg E, Tarnavski O, Zeisberg M, Dorfman A, McMullen J, Gustafsson E, Chandraker A, Yuan X, Pu W, Roberts A, Neilson E, Sayegh M, Izumo S,  Kalluri R . Endothelial to Mesenchymal Transition Contributes to Cardiac Fibrosis.  Nat Med.  2007 Aug;13(8):952-61.

Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H,  Kalluri R . Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.  J Biol Chem . 2007 Aug 10;282(32):23337-47.

Sugimoto H, Grahovac G, Zeisberg M, and  Kalluri R . Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and its Regression by BMP-7 and Advanced Glycation.  Diabetes . 2007 Jul;56(7):1825-33.

Garovic V, Wagner S, Petrovic L, Gray C, Hall P, Sugimoto H,  Kalluri R , Grande J. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.  Nephrol Dial Transplant . 2007 Apr; 22(4):1136-43.

Teng Y, Zeisberg M,  Kalluri R . Transcriptional regulation of epithelial-mesenchymal transition.  J. Clin. Invest.  2007 Feb 1;117(2):304-306. 

Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A,  Kalluri R , Shield CF 3rd, Sheppard D, Gardner HA, Violette SM. αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse.  Am J Pathol. 2007 Jan;170(1):110-25.

Sugimoto H, Yang C, LeBleu V, Soubasakos M, Giraldo M, Zeisberg M,  Kalluri R . BMP-7 functions as a novel hormone to facilitate liver regeneration.  FASEB J.  2007 Jan; 256-264.

Sugimoto H, Mundel T, Kieran M,  Kalluri R . Identification of Fibroblast Heterogeneity in the Tumor Microenvironment.  Cancer Biol Ther.  2006 Dec 5;5(12): 1640-1646. 

Kalluri R , and Zeisberg E. Controlling Angiogenesis in Heart Valves.  Nat. Med.  2006 12, 1118-1119.

Kalluri R . Proteinuria With and Without Renal Glomerular Podocyte Effacement.  J Am Soc Nephrol. 2006 Sep;17(9):2383-9. 

Farazi PA, Zeisberg M, Glickman J, Zhang Y,  Kalluri R , DePinho RA. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice.  Cancer Res. 2006 Jul 1;66(13):6622-7. (Kalluri and DePinho: Co-Corresponding Authors)

Sugimoto H, Mundel T, Sund M, Xie L, Cosgrove D,  Kalluri R . Bone Marrow Derived Stem Cells Repair Basement Membrane Collagen Defects and Reverse Genetic Kidney Disease.  Proc. Natl. Acad. Sci.  2006 May 9;103(19):7321-6.

Kalluri R , and Zeisberg M. Fibroblasts in Cancer.  Nature Rev Cancer  2006

Macdonald B, Sund M, Grant MA, Pfaff K, Holthaus K, Zon L,  Kalluri R . Zebrafish to humans: evolution of the α3-chain of type IV collagen and emergence of autoimmune epitopes associated with Goodpasture Syndrome.  Blood  Mar 2006;107:1908 - 1915.

Lee J, Dedhar S,  Kalluri R , Thompson E. The Epithelial-Mesenchymal Transition: New Insights in Signaling, Development and Disease.  J. Cell Bio  2006 Mar 27;172(7):973-81.

Zeisberg M, Khurana M, Rao V, Cosgrove D, Rougier JP, Werner M, Shield C, Werb Z,  Kalluri R . Stage-Specific Action of Matrix Metalloproteinases on Glomerular Basement Membrane Influences Progressive Hereditary Kidney Disease.  PLoS Med.  2006 Mar 7;3(4):e100.

Folkman J, Heymach J,  Kalluri R . Tumor Angiogenesis In:  Cancer Medicine 7th Ed , eds, JF Holland, E Frei III, RC Bast Jr, DW Kufe, RE Pollock, RR Weichselbaum, Hamilton, Ontario, Canada: BC Decker Inc., 2006; 157-191.

Sund M, Hamano Y, Sugimoto H, Sudhakar A, Soubasakos M, Yerramalla U, Benjamin L E, Lawler J, Kieran M, Shah A, and  Kalluri R . The Function of Endogenous Inhibitors of Angiogenesis as Endothelium-Specific Tumor Suppressors.  Proc. Natl. Acad. Sci.  2005; 102: 2934-9. 

Sudhakar A, Nyberg P, Li J, Sugimoto H, Cosgrove D,  Kalluri R . Human Type IV Collagen Alpha 1 NC1 Domain (Arresten) Exhibits Distinct Antiangiogenesis Activity Dependent on α1β1 Integrin.  J Clin Invest . 2005 Oct 1;115(10):2801-2810.

Reiser J, Polu KR, Moller, CC Kenlan P, Altintas MM, Wei C, Faul, C, Herbert S, Villegas I, Avila-Casado, C, McGee M, Sugimoto H, Brown D,  Kalluri R , Mundel P, Smith PL, Claham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.  Nat. Genet.  2005; 37(7):739-44

Sund M, Zeisberg M,  Kalluri R . Invited Review: Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical application.  Gastroenterology  2005; 129(6): 2076-91.

Nyberg P, Xie L,  Kalluri R . Endogenous Inhibitors of Angiogenesis.  Cancer Research  2005; 65:10.

Folkman J,  Kalluri R . Cancer without Disease.  Nature . 2004; 427:785.

Kalluri R . Basement membranes: structural features, assembly, cellular interactions and role in cancer angiogenesis.  Nature Rev Cancer . 2003; 3(6): 422-33.

Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F,  Kalluri R . BMP-7 counteracts TGFβ-1 induced epithelial to mesenchymal transition and reverses chronic renal injury.  Nat Med.  2003; 9(7): 964-8.

Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R . Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin.  Cancer Cell . 2003; 3(6): 589-601.

Sudhakar A, Sugimoto H, Yang CQ, Lively J, Zeisberg M,  Kalluri R . Human tumstatin and human endostatin exhibits distinct anti-angiogenic activities mediated by αvβ3 and α5β1 integrins.  Proc Natl Acad Sci.  2003; 100(8): 4766-71.

Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A,  Kalluri R . Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria.  J Biol Chem.  2003; 278(15): 12605-8.

Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO,  Kalluri R . Tumstatin: an endothelial cell-specific inhibitor of protein synthesis.  Science . 2002; 295(5552):140-3.

Maeshima Y, Colorado PC, Torre A, Holthaus KA, Grunkemeyer JA, Ericksen MB, Hopfer H, Xiao Y, Stillman IE,  Kalluri R . Distinct antitumor properties of a type IV collagen domain derived from basement membrane.  J Biol Chem.  2000; 275(28):21340-8.

Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R . Anti-angiogenic cues from vascular basement membrane collagen.  Cancer Res.  2000; 60(9):2520-6.

Kalluri R , Cantley LG, Kerjaschki D, Neilson EG. Reactive oxygen species expose cryptic epitopes associated with autoimmune Goodpasture syndrome.  J Biol Chem.  2000; 275(26):20027-32.

Kalluri R , Cosgrove D. Assembly of type IV collagen. Insights from α3(IV) collagen-deficient mice.  J Biol Chem.  2000; 275(17):12719-24.

Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme, VP,  Kalluri R . Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chem.  2000; 275(2):1209-15.

Kalluri R , Torre A, Shield CF III, Zamborsky ED, Werner MC, Suchin E, Wolf G, Helmchen UM, vd Heuvel L, Grossman R, Aradhye S, Neilson EG. Identification of α3, α4 and α5 chains of type IV collagen as alloantigens for Alport posttransplant anti-glomerular basement membrane antibodies.  Transplantation 2000; 69(4):679-83.

Kalluri R , Danoff TM, Okada H, Neilson EG. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.  J Clin Invest.  1997; 100(9):2263-75.

Kalluri R , Shield CF, Todd P, Hudson BG, Neilson EG. Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis.  J Clin Invest.  1997; 99(10):2470-8.