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AIDS Clinical Trial Group

The Infectious Disease Division at BIDMC is a member of the collaborative, NIH-funded Harvard/Boston Medical Center AIDS Clinical Trials Group (ACTG). This collaborative has conducted sentinel clinical trials evaluating antiretroviral therapy in ARV-naive and experienced participants and has participated in studies addressing the therapy and prophylaxis of AIDS-related opportunistic infections.

The BIDMC clinical site recruits and enrolls HIV-infected patients to ACTG-sponsored clinical studies that currently focus on evaluating the impact of HIV on end organ disease and inflammation, HIV reservoirs and viral eradication strategies; therapeutic strategies to improve HIV clinical management; and interventions to reduce selected coinfections, and AIDS related malignancies.

This site has implemented studies that evaluate the impact of antiretroviral strategies on bone health and neurocognitive function in ART-naive patients, evaluate the effectiveness of the quadrivalent HPV vaccine in preventing anal dysplasia in HIV-infected men; evaluate the use of novel antibiotic regimens in modulating gut microbial translocation and impact on systemic immune activation; assess effectiveness of promising new treatments for selected opportunistic infections, and evaluate specific treatment regimens for hepatitis C in co-infected patients.

The AIDS clinical research activities of the Division operate from the Infectious Disease Clinic. Dr. Mary Albrecht (the institutional Principal Investigator) leads this effort with support from Drs. John Doweiko, Lori Panther, and 1 study unit coordinator. This group also conducts industry-funded AIDS related clinical trials.

Dr. John Doweiko (who has a dual appointment in the Infectious Disease and Hematology-Oncology Divisions) coordinates trials of treatment for AIDS-related malignancies.

Dr. Lori Panther and Dr John Doweiko oversee a clinical and research oriented Anal Dysplasia Clinic within the Infectious Disease Clinic to investigate and treat human papilloma virus (HPV) infection, anal warts, and HPV induced anal cancer.