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Recent Division Publications

Schulman S, Furie B. How I treat: poisoning with vitamin K antagonists. Blood. 2014 Nov 6. pii: blood-2014-08-597781. [Epub ahead of print] PMID: 25377783.

Flaumenhaft R, Furie B, Zwicker JI.  Theraputic Implications of Protein Disulfide Isomerase Inhibition in Thrombotic Disease.  Arterioscler Thromb Vasc Biol. 2014 Aug 7. pii: ATVBAHA.114.303410 [Epub ahead of print] PMID: 2514801.

Proulle V, Furie RA, Merrill-Skoloff G, Furie BC, Furie B.  Platelets are required for enhances activation of the endothelium and fibrinogen in a mouse thrombosis model of APS. Blood. 2104 May 13. pii: blood-2014-02-554980. Epub 2014 May 13. PMID: 24825863.

Furie B, Flaumenhaft R. Thiol isomerases in thrombus formation.  Circ Res. 2014 Mar 28; 114(7):1162-73.  doi: 10.1161/CIRCRESHA.114.301808. Review.  PMID: 24677326.

Furie B. Do pharmacogenetics have a role in the dosing of vitamin K antagonists?  N Engl J Med. 2013 Dec 12;369(24):2345-6.  doi: 10.1056/NEJMe1313682.  Epub 2013 Nov 19.  PMID: 24251364.

Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, Mantha S, Kessler CM, Eneman J, Raghavan V, Lenz HJ, Bullock A, Buchbinder E, Neuberg D, Furie B. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study).  Br J Haematol. 2013 Feb;160(4):530-7. doi: 10.1111/bjh.12163.  Epub 2012 Dec 13. PMID: 23240761.

Furie B, Furie BC.  Formation of the Clot.  Thromb Res.  2012 Oct; 130 Suppl 1:S44-6. doi: 10.1016/j.thromres.2012.08.272.  Review.  PMID: 2302660

Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood. 2012 Jul 19;120(3):647-55. Epub 2012 May 31. PubMed PMID: 22653978.

Jasuja R, Passam FH, Kennedy DR, Kim SH, van Hessem L, Lin L, Bowley SR, Joshi SS, Dilks JR, Furie B, Furie BC, Flaumenhaft R. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest. 2012 Jun 1;122(6):2104-13. doi: 10.1172/JCI61228. Epub 2012 May 8. PubMed PMID: 22565308; PubMed Central PMCID: PMC3366406.

Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012 Feb 1;122(2):558-68. doi: 10.1172/JCI58969. Epub 2012 Jan 3. PubMed PMID: 22214850; PubMed Central PMCID: PMC3266787.

Zwicker JI, Lacroix R, Dignat-George F, Furie BC, Furie B. Measurement of platelet microparticles. Methods Mol Biol. 2012;788:127-39. PubMed PMID: 22130705.

Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE. Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo. J Biol Chem. 2011 Jul 1;286(26):23345-56. Epub 2011 Apr 29. PubMed PMID: 21531712; PubMed Central PMCID: PMC3123099.

Bellido-Martín L, Chen V, Jasuja R, Furie B, Furie BC. Imaging fibrin formation and platelet and endothelial cell activation in vivo. Thromb Haemost. 2011 May;105(5):776-82. Epub 2011 Mar 24. Review. PubMed PMID: 21437353.

Zwicker JI, Trenor CC 3rd, Furie BC, Furie B. Tissue factor-bearing microparticles and thrombus formation. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):728-33. Epub 2011 Jan 20. Review. PubMed PMID: 21252066.

Arad A, Proulle V, Furie RA, Furie BC, Furie B. β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 2011 Mar 24;117(12):3453-9. Epub 2011 Jan 18. PubMed PMID: 21245481; PubMed Central PMCID: PMC3069681.

Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem. 2011 Mar 4;286(9):7027-32. Epub 2011 Jan 3. PubMed PMID: 21199867; PubMed Central PMCID: PMC3044959.

Atkinson BT, Jasuja R, Chen VM, Nandivada P, Furie B, Furie BC. Laser-induced endothelial cell activation supports fibrin formation. Blood. 2010 Nov 25;116(22):4675-83. Epub 2010 Jul 30. PubMed PMID: 20675401; PubMed Central PMCID: PMC2996123.

Jasuja R, Furie B, Furie BC. Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo. Blood. 2010 Nov 25;116(22):4665-74. Epub 2010 Jul 28. PubMed PMID: 20668226; PubMed Central PMCID: PMC2996122.

Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem. 2010 Mar 19;285(12):8824-9. Epub 2010 Jan 20. PubMed PMID: 20089867; PubMed Central PMCID: PMC2838304.