Lab Members
Barbara C. Furie PhD
Director, Center for Hemostasis and Thrombosis Research
Hematology/Oncology Division, Department of Medicine
Beth Israel Deaconess Medical Center
Professor of Medicine, Harvard Medical School
Phone: 617-667-0620
Email: barbara@earl.bidmc.harvard.edu
Interested in the posttranslational processing of blood clotting proteins, she has made major contributions to our knowledge of the molecular basis of -carboxylation and of the role of -carboxyglutamic acid in the calcium binding properties of the vitamin K-dependent blood clotting proteins. Her current work includes the study of the mechanism of action of the vitamin K-dependent carboxylase and its interaction with vitamin K. In collaboration, she is also studying the assembly of blood coagulation complexes on the membrane surfaces using X-ray crystallographic techniques. Dr. Furie has served and is again serving on the Hematology Study Section of the NIH for which she had served as Chairperson. Dr. Furie was the recipient of the William Dameshek Prize of the American Society of Hematology in 1984 and an Outstanding Investigator Award from the International Society of Thrombosis and Hemostasis. She was a recipient of a MERIT Award from the NHLBI, National Institutes of Health and served on the Editorial Board of Blood .
Bruce Furie MD
Director, Beth Israel Deaconess Cancer Center
Beth Israel Deaconess Medical Center
Professor of Medicine, Harvard Medical School
Phone: 617-667-0620
Email: bfurie@earl.bidmc.harvard.edu
Dr. Furie's research interests focus within the area of hemostasis and thrombosis. Major activities in the laboratory involve the study of the structure-function relationships of the blood coagulation proteins, with special attention directed toward the vitamin K-dependent proteins, and the assembly of Factor IX and Factor VIII on membrane surfaces. He has been involved in defining the molecular basis of hemophilia, particularly hereditary Factor IX deficiency. In addition, the structure and function of platelet glycoprotein receptors, including P-selectin, a cellular adhesion molecule discovered in this laboratory, remains an important activity. A PSGL-1 knockout mouse has recently been generated by this laboratory, and animal models are being performed to explore the biology of PSGL-1, the P-selectin counterreceptor on myeloid cells. The laboratory has recently used NMR spectroscopy to determine the structure of the -carboxyglutamic acid domain of Factor IX and to identify the phospholipid binding sites of vitamin K dependent proteins. With Dr. Barbara Furie, Dr. Bruce Furie was the recipient of the William Dameshek Prize of the American Society of Hematology in 1984. He was the recipient of a MERIT Award from the NHLBI, National Institutes of Health. Dr. Furie is a co-editor of the hematology textbook, Hematology: Basic Principles and Practice .
Alan Rigby PhD
Hematology/Oncology Division, Department of Medicine
Beth Israel Deaconess Medical Center
Instructor in Medicine, Harvard Medical School
Phone: 617-667-0637
Email: arigby@bidmc.harvard.edu
David Roth MD
Hematology/Oncology Division, Department of Medicine
Beth Israel Deaconess Medical Center
Assistant Professor of Medicine, Harvard Medical School
Email: droth@bidmc.harvard.edu
Dr. Roth is interested in the molecular and developmental biology of blood coagulation. The focus of his laboratory has been in the regulation of vitamin K-dependent carboxylation, the developmental functions of vitamin K-dependent proteins, and the role of vitamin K-dependent proteins as ligands for cell surface proteins. Using methods to analyze gene expression in a rat embryo model, he has identified that the expression of the vitamin K-dependent carboxylase gene is developmentally regulated. His current laboratory efforts focus on basic molecular biology approaches and studies in transgenic animals to elucidate gene transcription mechanisms underlying developmental regulation of gene expression. His laboratory is also evaluating underlying mechanisms of warfarin embryopathy with functional studies of vitamin K-dependent proteins expressed in embryonic tissues using tissue culture and in vivo embryo model systems. Dr. Roth is the principal investigator on the first human gene therapy trial for the treatment of hemophilia A. This trial is currently active.
Postdoctoral Fellows
Gail Begley PhD
Mark Blostein MD
Beth Bouchard PhD
Ludmila Bronstain PhD
Kris Bush PhD
Jane Carleton MD
Kevin Croce MD PhD
Eva Czerwiec PhD
Lisa Falls PhD
Robert Flaumenhaft MD PhD
Paula Fraenkel MD
Takako Hirata MD PhD
Guiqing Huang PhD
Qingde Liu MD PhD
Daqling Qu PhD
Boris Tchernychev PhD
Graduate Students
Jonathan Tward
Research Assistants
Margaret Jacobs Protein sequencing/peptide synthesis core laboratory Kathy Reebenbacker Tissue culture core laboratory Glenn Merrill-Skoloff Animal core laboratory facilities Elizabeth Romero
Administration
Carla Powdermaker
Phone: 617-667-0620
E-mail: cpowderm@bidmc.harvard.edu
