beth israel deaconess medical center a harvard medical school teaching hospital

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Selected Publications

Dowal L, Sim DS, Dilks JR, Blair P, Beaudry S, Denker B, Koukos G, Kuliopulos A, Flaumenhaft R. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. PNAS. In press.

Liu J, Gao B, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Hyperglycemia Induced Cerebral Hematoma Expansion is Mediated by Plasma Kallikrein. Nature Medicine. In press.

Woronowicz K, Dilks JR, Rozenvayn N, Dowal L, Woronowicz L, and Flaumenhaft R. The platelet actin cytoskeleton associates with SNAREs and participates in granule secretion. Biochemistry. 2010. 49:4533-42.

Graham GJ, Ren Q, Dilks JR, Blair P, Whiteheart SW, and Flaumenhaft R. Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo. Blood. 2009. 114(5):1083-90.

Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE. Megakaryocyte-derived microparticles: Direct visualization and distinction from platelet-derived microparticles. Blood. 2009. 113(5): 1112-21.

Flaumenhaft R, Rozenvayn N, Feng D, and Dvorak AM. SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. Blood. 2007;110(5):1492-501.

Flaumenhaft R, Graham GG, De Grand AM, Laurence RG, Tanaka E, Hoshino K, Hajjar RJ, and Frangioni JV. Localization and quantification of platelet-rich thrombi in large vessels using near-infrared fluorescence imaging. Circulation. 2007;115(1):84-93.

Sim DS, Dilks JR, Flaumenhaft R. Platelets possess and require an active protein palmitoylation pathway for agonist-mediated activation and in vivo thrombus formation. 2007; Arterioscler Thromb Vasc Biol; 27(6):1478-85.

Flaumenhaft R, Dilks J, Rozenvayn N, Monahan-Earley RA, Feng D, and Dvorak AM. The actin cytoskeleton differentially regulates platelet -granule and dense granule secretion Blood. 2005; 105(10):3879-87.

O'Connell DJ, Rozenvayn N, and Flaumenhaft R. Phosphatidylinositol (4,5)-bisphosphate regulates activation-induced platelet microparticle formation. Biochemistry. 2005; 26: 44(16):6361-70.

Sim DS, Merrill-Skoloff G, Furie BC, Furie B, and Flaumenhaft R. Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood. 2004; 103: 2127-2134.

Lai KC and Flaumenhaft R. SNARE protein degradation upon platelet activation:
Calpain cleaves SNAP-23. J Cell Physiol. 2003; 194(2): 206-214.

Rozenvayn N and Flaumenhaft R. Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion. J Biol Chem. 2003; 278(10): 8126-34.

Feng D, Crane K, Rozenvayn N, Dvorak AM, and Flaumenhaft R. Subcellular distribution of three functional platelet SNARE proteins: Human cellubrevin, SNAP-23, and syntaxin 2. Blood. 2002; 99: 4006-4014.

Rozenvayn N and Flaumenhaft R. Phosphatidylinositol (4,5)-bisphosphate mediates Ca2+-induced platelet alpha-granule secretion: Evidence for type II phosphatidylinositol 5-phosphate 4-kinase-dependent function. J Biol Chem. 2001; 276: 22410-9.

Yang J, Hirata T, Croce K, Merrill-Skoloff G, Tchernychev B, Williams E, Flaumenhaft R, Furie BC, and Furie B. Targeted gene disruption demonstrates that PSGL-1 is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med. 1999; 190: 1769-1782.

Flaumenhaft R, Croce K, Chen E, Furie BC, and Furie B. Proteins of the exocytotic core complex mediate platelet -granule secretion: Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4. J Biol Chem. 1999; 274: 2492-2501.