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Publications

Original Articles:

1. Lu K.P., S. H. Chao and D. S. Wang. 1988, Involvement of calcium and calmodulin in the proliferation of aortic smooth muscle cells.  Chin. J. Pharmac. Toxicol. 2:166-170.
2. Lu, K. P., S. H. Chao and D. S. Wang. 1990, The stimulatory effect of heavy metal cations on the proliferation of aortic smooth muscle cells. Sci. China 'B 33(3):303-310.
3. Rasmussen, C. D., Means, R. L., Lu, K. P., May, G. S. and Means, A. R. 1990, Characterization and expression of the unique calmodulin gene of Aspergillus nidulans. J. Biol. Chem. 265, 13767-13775.
4. Lu, K. P., Rasmussen, C. D., May, G. S., and Means, A. R. 1992, Cooperative regulation of cell proliferation by calcium and calmodulin
in Aspergillus nidulans. Mol. Endocrinol. 6:365-374.
5. Lu, K. P., Osmani, A. H. and Means, A. R. 1993, Properties and regulation of the cell cycle specific NIMA protein kinase of Aspergillus nidulans. J. Biol. Chem. 268:8769-8776.
6. Lu, K. P., Osmaini, S. A. and Means, A. R. 1993, Essential roles for calcium and calmodulin at G2/M progression in Aspergillus nidulans. J. Cell Biol. 121:621-630.
7. Pan, M-G., Rim, C., Lu, K. P. Florio, T. and Stork, P. J. S. 1993, Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene. J. Biol. Chem. 268:19284-19291.
8. Lu, K. P., Kemp, B. E. and Means, A. R. 1994, Identification of the substrate specificity determinants of the cell cycle-specific NIMA protein kinase. J. Biol. Chem. 269:6603-6607.
9. Lu, K. P. and Means, A. R. 1994, Expression of the noncatalytic domain of the NIMA protein kinase causes a G2 arrest in Aspergillus nidulans. EMBO J. 132:103-2113.
10. Lu, K. P. and Hunter, T. 1995, Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81:413-424.
11. Lu, K. P., Hanes, S. D. and Hunter, T. 1996, A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380:544-547.
12. Songyang, Z., Lu, K. P., Kuan, Y., Tsai, L.-H., Filhol, O., Cochet, C., Soderling, T. R., Bartleson, C., Graves, D. J., Hoekstra, M. F., Blenis, J. Hunter, T. and Cantley, L. C. 1996, A structural basis for substrate specificities of protein Ser/Thr-kinases: Primary sequence preference of casein kinase I and II, NIMA, phosphorylase
kinase, CaM kinase II, CDK5 and Erk1. Mol. Cell. Biol. 16:6486-6493.
13. Ranganathan, R., Lu, K. P., Hunter, T. and Noel, J. 1997, Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89: 875-886.
14. Shen, M., Vogt, V., Haggblom, C., Hunter, T. and Lu, K. P. 1997, Characterization and cell cycle regulation of related human telomeric proteins Pin2 and TRF1 suggests a role in mitosis. Proc. Natl. Acad. Sci. USA 94: 13618-1362
15. Yaffe, M., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J.-U., Xu, J., Kuang, J., Kirschner, M. W., Fischer, G., Cantley, L. and Lu, K. P. 1997, Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science 278:1957-1960 (Comment in Science 278:1883-1884).
16. Shen, M., Stukenberg, P. T., Kirschner, M. W. and Lu, K. P. 1998, The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 12: 706-720.
17. Schutkowski, M., Bernhardt, A. Zhou, X. Z., Shen, M., Reimer, U., Rahfeld, J.-U. P., Lu, K. P. and Fischer, G. 1998, Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition. Biochemistry 37:5566-5575.
18. Lu, P.-J., Zhou, X. Z., Shen, M. and Lu, K. P. 1999, Function of WW domains as phosphoserine or phosphothreonine-binding modules. Science 283:1325-1328 (Comment in Science 283:1248-1249).
19. Mounsey, J. P., Lu, K. P., Patel, M. K., Chen, Z. H., Horne, L. T., John, J. E. III, Means, A. R., Jones, L. R. and Moorman, J. R. 1999, Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. Biochim Biophys Acta. 1451:305-18.
20. Lu, P.-J., Wulf, G., Zhou, X. Z., Davies, P. and Lu, K. P. 1999, Prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399:784-788 (News and Views Comment in Nature, 399:739-740).
21. Ott, D. E., Goren, L. V., Johnson, D. G., Kane, B. P., Sowder, R. C., Kim, Y. D., Fisher, R. J., Zhou, X. Z., Lu, K. P. and Herderson, L. E. 1999, Actin-binding cellular protein inside human immunodeficiency virus type 1. Virology 266:42-51.
22. Gerez, L. Mohrmann, K.va Raak, M. Zhou, X. Z., Lu, K. P. and van der Sluijs, P. 2000, Accumulation of Rab4 in the cytoplasm and interaction with the prolyl isomerase Pin1 during mitosis. Mol. Biol. Cell 11:2201-2211.
23. Lee, S. M. Fang, L., Reimer, C. L., Arizti, P., Lu, K. P. and Aaronson, S. A. 2000, Sustained activation of the MAP kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA 97:8302-8305.
24. Verdecia, M.A., Bowman, M. E., Lu, K. P., Hunter, T. and Noel, J. P. 2000, Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat. Struct. Biol. 7:639-643 (News and Views Comment in Nat. Struct. Biol. 7:611-6133).
25. Zhou, X. Z., Kops, O., Werner, A., Shen, M. Lu, P. J., Küllertz, G., Fischer, G., and Lu, K. P. 2000. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and Tau protein. Mol. Cell 6: 873-883.
26. Yao, J.-L., Kops, O., Lu, P.-J. and Lu, K. P. 2001. Functional conservation of phosphorylation-specific prolyl isomerases in plants. J. Biol. Chem. 276:13517-13523
27. Metzner, M., Stoller, G., Rucknagel, K. P., Lu, K. P. Fischer, G., Luckner, M. and Kullertz, G. 2001. Functional replacement of the essential ESS1 in yeast by the plant DlPin1. J. Biol. Chem. 276:13524-13529
28. Kishi, S., Wulf, G. M., Nakamura, M. and Lu, K. P. 2001, Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. Oncogene 20:1497-1508.
29. Nakamura, M. Zhou, X. Z. and Lu, K. P. 2001. Critical role for the EB1 and APC interaction in the regulation of microtubule dynamics. Curr Biol. 11:1062-1067.
30. Liu, W., Youn, H., Zhou, X. Z., Lu, K. P., and Liu, J. O. 2001. Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1. FEBS Lett. 496:105-108.
31. Kishi, S., Zhou, X. Z., Ziv, Y., Shen, M., Khoo, C., Hill, D. E. Shiloh, Y. and Lu, K. P. 2001, Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J. Biol. Chem. 276: 29282-29291.
32. Wulf, G. M., A. Ryo, Wulf, G. G., Lee, S. W., Niu, T. and Lu, K. P. 2001. Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylated c-Jun towards the cyclin D1 gene. EMBO J. 20: 3459-3472.
33. Ryo. A., Wulf, G. M., Nakamura, M. Liou, Y. Lu, K. P. 2001. Pin1 regulates turnover and subcellular localization of beta-catenin by modulating its interaction with the tumor suppressor APC. Nature Cell Biol. 3: 793-801.
34. Nakamura, M. Zhou, X. Z., Kosugi, I., Tsutsui Y. and Lu, K. P. 2001. Specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Curr Biol. 11:1512-1516.
35. Zhou, X.Z. and Lu, K.P. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-59
36. Lu, P. J.,Zhou, X. Z., Liou, Y. C., Noel, J. P. and Lu, K. P. 2002. Critical role of WW domain phosphorylation in regulating its phosphoserine-binding activity and Pin1 function. J. Biol Chem. 277:2381-2384 (Accelerated Publication)
37. Kishi S and Lu KP. 2002. A critical role for Pin2/TRF1 in ATM-dependent regulation: Inhibition of Pin2/TRF1 function complements telomere shortening, the radiosensitivity and G2/M checkpoint defect of Ataxia-Telangiectasia cells. J. Biol Chem. 277:7420-7429
38. Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P. J., Fujimori, F., Uchida, T. Bronson, R. Hunter, T. and Lu, K. P. 2002. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1 null phenotyes. Proc. Natl. Acad. Sci. USA. 99:1335-1340 (track II Submission) 39. Nakamura, M. Zhou, X.Z., Kishi, K. and Lu, K.P. 2002, Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 514:193-198 (This paper has won the most outstanding research paper award in FEBS letter in 2002) 40. Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P. J., Fujimori, F., Uchida, T. Bronson, R. Hunter, T. and Lu, K. P. 2002, Loss of Pin1 function in the mouse resembles the cyclin D1-null phenotypes. Proc. Natl. Acad. Sci. USA 99:1335-1340 (Track II direct submission). 41. Ryo, A., Liou, Y. C., Wulf, G., Nakamura, M., Lee, S. W., and Lu, K. P. 2002. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22:5281-5295.
42. Wulf, G. M., Liou, Y. C., Ryo, A., Lee, S. W., and Lu, K. P. 2002. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J. Biol. Chem. 277:47976-47979.
43. Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K. P. and Xiao, Z. X. 2002. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419:849-853 (News and Views Comment in Nature 419:829-831).
44. Ayala1, G., Wang, D., Wulf, G., Kimzey, A., Frolov, A., Le, R., Sowadski, J., Wheeler, T., Lu, K. P.* and Bao, L.* 2003. Pin1 is a novel prognostic marker in prostate cancer. Cancer Res. (in press). (* share co-correspondent authors).
45. Liou, Y.-C., Sun, A., Ryo, A., Zhou, X. Z., Yu, Z.-X., Huang, H.-K., Bronson, R., Uchida, T., Bing, G., Li, X., Hunter, T. and Lu, K. P. 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424: 556-561.
46. Ayala1, G., Wang, D., Wulf, G., Kimzey, A., Frolov, A., Le, R., Sowadski, J., Wheeler, T., Lu, K. P.* and Bao, L.* 2003, Pin1 is a novel prognostic marker in prostate cancer. Cancer Res. 63: 6244-6251. (* contribute equally and share the senior authorship). 47. Xu, Y.-X., Hirose, Y., Zhou, X. Z., Lu, K. P. and Manley, J. L. 2003, Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev. 17: 2765-2776. 48. Ryo, A., Suizu, F., Yoshida, Y., Perrem , K., Liou, Y. C., Wulf, G., Rottapel, R., Yamaoka, S., and Lu, K. P. 2003, Regulation of NF-kappaB signaling by Pin1-catalyzed prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12: 1413-1426 (Preview: Mol. Cell 12: 1344-1345). 49. Bao, L., Kimzey, A., Sauter, G., Sowadski, J., Lu, K. P.* and Wang, D.* 2004, Prevalent Overexpression of Prolyl Isomerase Pin1 in Human Cancers. Am. J. Pathol. 164: 1727-1737 (* contribute equally and share the senior authorship). 50. Kim, K.-T., Ongusaha, P. P., Hong, Y. K., Kurdistani, S. K., Nakamura, M., Lu, K. P. and Lee, S. W. 2004, Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J. Biol. Chem. 279: 38597-602. 51. Wulf, G., Garg, P., Liou, Y. Y., Iglehart, D. and Lu, K. P. 2004, Modeling breast cancer in vivo and ex vivo uncovers an essential role for Pin1 in tumorigenesis. EMBO J. 23: 3397-3407. 52. Dougherty, M. K., Müller, J., Ritt, D. A., Zhou, X. Z., Zhou, M., Copeland, T. D., Conrads, T. P., Veenstra, T., Lu, K. P. and Morrison, D. K. 2005, Regulation of Raf-1 by direct feedback phosphorylation. Mol. Cell 17: 215-224.

Invited Reviewers and Chapters:

1. Lu, K. P., S. H. Chao and D. S. Wang. 1989, Calmodulin: A possible regulatory factor in the proliferation of vascular smooth muscle cells. Chin. Sci. Bull. 34:174-175.
2. Means, A. R., VanBerkum, M. F. A., Bagchi, I. C., Lu, K. P. and Rasmussen, C. D. 1991, Regulatory functions of calmodulin. Pharmac. Ther. 50:255-270.
3. Rasmussen, C. D., Lu, K. P., Means, R. L. and Means, A. R. 1992, Calmodulin and cell cycle control. J. Physiol. 86:83-88.
4. Lu, K. P. and Means, A. R. 1993, Regulation of the cell cycle by calcium and calmodulin. Endocrine Rev. 14:40-58.
5. Lu, K. P. and Means, A. R. 1993, Conditional mutants for studying functions of calmodulin in Aspergillus nidulans. Meth. Mol. Gen. 2:255-275.
6. Lu, K. P., Nanthakumar, N. N., Dayton, J. S. and Means, A. R. 1995, Calcium and calmodulin regulation of the nuclear division cycle of Aspergillus nidulans. Adv. Mol. Cell Biol. 13::89-136.
7. Eldbredge, E. R., Chiao, P. J. and Lu, K. P. 1995, Use of tetracycline operator system to regulate oncogene expression in mammalian cells. Meth. Emzymol. 254:481-490.
8. Lu, K. P. and Hunter, T. 1995, The NIMA kinase: A mitotic regulator in Aspergillus nidulans and vertebrate cells. Progr. in Cell Cycle Res. 1:187-205.
9. Lu, K. P. and Hunter, T. 1997, Pin1. in Guidebook to Molecular Chaperones and Protein Folding Catalysts (M.-J. Gething, ed.). pp443-446. Oxford University Press. Oxford.
10. Lu, K. P. 1999, The essential peptidyl-prolyl isomerase Pin1 is a phosphorylation-dependent mitotic modulator. in Future Aspects in Peptide Chemistry (W. Voelter and G. Fischer, eds.). Vol. 1, pp 178-186.
11. Zhou, X. Z., Lu, P. J. and Lu, K. P. 1999, Phosphorylation-dependent prolyl isomerization: A novel signaling regulatory mechanism. Cell. Mol. Life Sci. 56: 788-806.
12. Lu, K. P. 2000, Phosphorylation-dependent prolyl isomerization: A novel cell cycle regulatory mechanism. Progr. Cell Cycle Res. 4:83-96.
13. Lu, K. P. 2002, Pin1. Encyclopedia of Mol. Med. pp 2498-2501.
14. Lu, K. P., Liou, Y. C., and Zhou, X. Z. 2002. Pinning down proline-directed phosphorylation signaling. Trends Cell Biol. 12:164-172. 15. Lu, K. P., Liou, Y. C., and Vincent, I. 2003. Role of proline-directed phosphorylation and isomerization in mitotic regulation and Alzheimer's disease. BioEssays 25:174-181.
16. Wulf, G., Ryo A., Liou, Y. C., and Lu, K. P. 2003. Prolyl isomerase Pin1 in mammary gland development and breast cancer. Breast Cancer Res. 5: 76-82.
17. Ryo A., Liou, Y. C., Lu, K. P.* and Wulf, G.* 2003. Prolyl isomerase Pin1, A catalyst for oncogenesis and a potential anticancer target. J. Cell Sci. 116: 773-783. (* share co- correspondent authors)
18. Zhou, X. Z., Perrem, K. and Lu, K. P. 2003. Role of Pin2/TRF1 in telomere maintenance and the cell cycle. J. Cell. Biochem. 89: 19-37.
19. Lu, K. P. 2003. Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics. Cancer Cell 4: 175-180 20. Lim J. and Lu, K. P. 2005, Pinning down phosphorylated tau and tauopathies. Biochim. Biophys. Acta. 1739: 311-322 21. Pastorino, L. and Lu, K. P. 2005, Phosphorylation of the amyloid precursor protein (APP): is this a mechanism in favor or against Alzheimer¹s disease. NRC. (in press). 22. Wulf, G. Finn, G. Suizu, F. and Lu, K. P. 2005, Pin1-dependent prolyl isomerization: Is there an underlying theme? Nature Cell Biology (in press).