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Publications

Vera Novak, MD PhD

Publications

 

  1. Manor B, Hu K, Zhao P, Selim M, Alsop DC, Novak P, Lipsitz LA, Novak V. Altered control of postural sway following cerebral infarction: a cross-sectional analysis. Neurology 2010,74: 448-449.
  2. Novak V, Hu K, Desrochers L, Novak P, Caplan L, Lipsitz L, Selim M: Cerebral flow velocities during daily activities depend on blood pressure in patients with chronic ischemic infarctions. Stroke 2010,41:61-66.
  3. Hajjar I.; Hart M, Millberg W, Novak V, Lipsitz L. The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition. BMC Geriatrics 2009, 9:48.
  4. Hajjar I; Zhao, P; Alsop D, Abduljalil A, Selim M, Novak P, Novak V: Association of blood pressure elevation and nocturnal dipping with brain atrophy, perfusion and functional measures in stroke and non-stroke individuals. Am. J. Hypertension. 2009, epub Oct 1. (PMID19798036).
  5. Lou M, Al-Hazzani A, Goddeau R, Novak V, Selim M. Relationship between White Matter Hyperintensities and Hematoma Volume and Growth in Patients with Intracerebral Hemorrhage. Stroke, 2010.41:34-40.
  6. Lo MT, Novak V, Peng CK, Liu Y, Hu K. Nonlinear phase interaction between nonstationary signals: A comparison study of methods based on Hilbert-Huang and Fourier transforms. Physical Review E., 2009 Accepted May 28 (EA10615).
  7. Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D: White matter hyperintensities and dynamics of postural control. Magnetic Resonance Imaging, 2009, 6:752-9.
  8. Pope SR, Ellwein LM, Zapata CL, Novak V, Kelly CT, Olufsen MS. Estimation and identification of parameters in a lumped cerebrovascular model. Mathematical Biosciences and Engineering, 2009:6, 1: 93-115.
  9. Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M. Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift. J. Neurotrauma, 2009 Jan 23 Epub.009.
  10.  Zhao P, Alsop D, Abduljalil A, Selim M, Lipsitz L, Novak P, Caplan L, Hu K, Novak V. Regional distribution of cerebral perfusion ,vasoreactivity and persistent infarct hyperintensities in ischemic stroke patients. Neurology 2009,72:643-9.
  11. Selim M, Jones R, Novak P, Zhao P, Novak V. The effects of body mass index on cerebral blood flow velocity. Clinical Autonomic Research, 2008, 6: 331-8.
  12. Devault K, Gremaud PA, Novak V, Olufsen MS, Vernieres G, Zhao P. Blood flow in the circle of Willis: Modeling and calibration. In press Multiscale Modeling and Simulation, 2008.
  13. Men-Tzung Lo, Kun Hu, Yanhui Liu, C.-K. Peng, Novak V. Multimodal Pressure Flow Analysis Enables Assessment of Cerebral Autoregulation Dynamics During Baseline Resting Conditions. EURASIP Journal on Advances in Signal Processing, In Press, 4-14-2008.
  14.  Hu K, Scheer FAJL, Buijs RM, Shea SA. The Circadian Pacemaker Generates an Endogenous Circadian Rhythm in the Fractal Structure of Heart Rate in Nocturnal Rats. Cardiovascular Research. 2008 [PMID: 18539630].
  15. Hu K, Scheer FAJL, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008; 23(3):265-73.
  16. Batzel JJ, Novak V, Kappel F,Olufsen MS, Tran HT. Introduction to the special issues: Short-term cardiovascular- respiratory control. Cardiovasc. Engineering 2008,8:1-4.
  17. Hajjar I, Selim M, Novak P, Novak V. The relationship between nighttime dipping in blood pressure and cerebral hemodynamics in nonstroke patients. J. Clin. Hypertens (Greenwich), 2007 12: 929-936.
  18. Ellwein LM, Tran HT, Zapata C, Novak V, Olufsen MS. Sensitivity analysis and model assessment: Mathematical models for arterial blood flow and pressure. Cardiovascular Engineering, 2007 Dec 15 (Epub).
  19. Hu K, Peng CK, Huang NE, Wu Z, Lipsitz LA, Cavallerano J, Novak V. Altered phase interactions between spontaneous blood pressure and flow fluctuations in type 2 diabetes mellitus: Nonlinear assessment of autoregulation. Physica A, 2008 387: 2279-2292.
  20. Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythms in human motor activity uncoupled from circadian influences on cardiac dynamics. Proc Natl Acad Sci. 2007; 104(52): 20702.
  21. Hu K, Scheer FAJL, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation, Neuroscience, 2007;149:508-17.
  22. Olufsen M, Alston AV. Tran HT, Ottesen JT, Novak V. Modeling heart rate regulation- part I. Sit-to-stand versus head-up tilt. Cardiovascular Engineering, 2007 Dec 6 (Epub).
  23. Hu K, Peng CK, Czosnyka M, Zhao P, Novak V. Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral perfusion pressure fluctuations. Cardiovascular Engineering, 2008:8:60-71.
  24. Last D, Alsop DC, Abduljalil AM, Marquis RP, de Bazelaire C, Hu K, Cavallerano J, Novak V: Global and regional effects of type 2 diabetes mellitus on brain tissue volumes and vasoreactivity. Diabetes Care 2007; 30: 1193-99.
  25. Novak V, Hu K, Vyas M, Lipsitz L: Cardio-locomotor coupling in young and old. J. Gerontology A Biol Sci Med Sci. 2007;62:86-92.
  26. Olufsen MS, Tran HT, Ottesen JT, Research Experiences for Undergraduates Program, Lipsitz LA, Novak V: Modeling baroreflex regulation of heart rate during orthostatic stress. Am. J. Physiol (Heart and Regulatory Physiol), 291R1355-68. Rated as one of the most read articles in Oct issue AJP 2006.
  27. Chen Z, Hu K, Stanley E, Novak V*, Ivanov P: Cross correlation of instantaneous phase increments in pressure-flow fluctuations: Applications to cerebral autoregulation. Virtual Journal of Biological Physics Research, 11, 6 March 15, 2006. *VN and PI contributed equally to this manuscript.
  28. Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA:. Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes mellitus. Diabetes Care, 29 1529-1534, 2006.
  29. Novak P, Novak V: Effect of step-synchronized vibration stimulation of soles upon gait in Parkinson's disease: A pilot study. Journal of NeuroEngineering & Rehabilitation, May 3:9, 2006.
  30. Xu L, Ivanov PCh, Hu K, Chen Z, Carbone A, Stanley HE. Quantifying signals with power-law correlations: A comparative study of detrended fluctuation analysis and detrended moving average techniques. Phys Rev E 2005;71:851101.
  31. Chen Z, Hu K, Stanley E, Novak V*, Ivanov P. Cross correlation of instantaneous phase increments in pressure-flow fluctuations: Applications to cerebral autoregulation. Physics Review E 73, 03195, 2006. *VN and PI contributed equally to this manuscript.
  32. Olufsen MS, Ottesen JT, Tran HT, Ellwein LM, Lipsitz LA, Novak V:. Blood pressure and blood flow variation during postural change from sitting to standing - mathematical modeling and experimental validation. J. Appl. Physiol. 2005, 99 1523-37.
  33. Hessert MJ, Vyas M, Leach J, Lipsitz L, Novak V: Foot pressure distribution in young and old. BMC Geriatrics. BMC Geriatrics 2005; 5:8.
  34. Lagerlund TD, Low PA, Novak V, Novak P, Hines SM, McPhee B, Busacker NE: Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome. Autonom. Neurosci. 2005;117:132-42.
  35. Novak V, Abduljalil A, Novak P, Robitaille PM: High resolution ultra high field MRI of stroke. Magn. Reson. Imaging 2005; 23:539-48.
  36. Ivanov PCh, Chen Z, Hu K, Stanley HE. Multiscale aspects of cardiac control, Physica A 2004;344:685-704.
  37. Hu K, Ivanov PCh, HiltonMF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythms in an index of cardiac vulnerability independent of changes in behavior. Proc Natl Acad Sci 2004;101:18223-18227.
  38. Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-Random Fluctuations and Multiscale Dynamics Regulation of Human Activity, Physica A 2004;337:307-318.
  39. Chen Z, Hu K, Carpena P, Bernaola-Galvan P, Stanley HE, Ivanov PCh. Effect of nonlinearity on detrended fluctuation analysis. Phys Rev E 2004;71:113501.
  40. Angelini L, De Tommaso M, Guido M, Hu K, Ivanov PCh, Marinazzo D, Nardulli G, Nitti L, Pellicoro M, Pierro C, and Stramaglia S. Steady state visual evoked potentials and phase synchronization in migraine. Phys Rev Lett 2004;93:038103.
  41. Novak V, Yang ACC, Lepicovsky L, Goldberger AL, Lipsitz LA, Peng CK: Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension. BioMedical Engineering OnLine 2004, 3:39 (Oct 25, 2004).
  42. Novak V, Chowdhary A, Abduljalil AM, Novak P, Chakeres D: Venous cavernoma at 8 Tesla MRI. Magn. Reson. Imaging 2003; 21:1087-9.
  43. Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW: Enhanced gray and white matter contrast of phase susceptibility weighted images at ultra high field MRI. J. Magn. Reson. Imaging 2003; 18:284-90.
  44. Novak V, Chowdhary A, Farrar B, Nagaraja H, Braun J, Kanard R, Novak P, Slivka A: Altered cerebral vasoregulation in hypertension and stroke. Neurology 2003; 60: 1657-63.
  45. Chakeres DW, Abduljalil AM, Novak P, Novak V: Case report: Comparison of 1.5 and 8 Tesla high-resolution magnetic resonance imaging of lacunar infarcts J. Comp. Assist. Tomogr. 2002; 26: 628-32.
  46. Deschamps A, Backman SB, Novak V, Plourde G, Fiset P, Chartrand D: Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans. J. Pharmacol. Exper. Ther. 2002; 300: 112-7.
  47. Chen Z, Ivanov PCh, Hu K, Stanley HE. Effect of nonstationarities on detrended fluctuation analysis. Phys Rev E 2002;265:041107.
  48. Hu K, Ivanov PCh, Chen Z, Carpena P, Stanley HE. Effect of trends on detrended fluctuation analysis. Phys Rev E 2001;64:011114.
  49. Novak V, Kanard, R, Kissel JT, Mendell JRM: Treatment of painful neuropathy with Tiagabine. Clin. Auton. Res. 2001, 11: 357-61.
  50. Novak V, Abduljalil A, Kangarlu A, Bourekas E, Slivka A, Novak P, Chakeres D: Intracranial ossification and microangiopathy at 8 Tesla MRI. Magn. Reson. Imaging 2001; 19: 1133-7.
  51. Novak V, Kangarlu A, Abduljalil A, Novak P, Slivka A, Chakeres D, Robittaille PM. Ultra high field MRI of subacute hemorrhagic stroke at 8 Tesla. J. Comp. Assist. Tomogr. 2001; 25: 431-35.
  52. Novak V, Freimer M, Kissel, JT, Sahenk, Z, Periquet IM, Nash S, Periquet IM, Collins M, Mendell JR: Autonomic impairment in painful sensory neuropathy. Neurology 2001; 56: 861-68.
  53. Novak P, Novak V, Kangarlu A, Abduljalil A, Chakeres D, Robittaille P: High resolution MRI of the brainstem at 8 Tesla. J. Comp. Assist. Tomogr. 2001; 25: 242-46.
  54. Gordon VM, Opfer-Gehrking TL, Novak V, Low PA: Hemodynamic and symptomatic effects of acute interventions on tilt in patients with the postural tachycardia syndrome. Clin. Auton. Res. 2000; 10: 29-33.
  55. Sandroni P, Novak V, Opfer-Gehrking TL, Huck, CA and Low PA: Mechanisms of blood pressure alterations in response to the Valsalva maneuver postural tachycardia syndrome. Clin. Auton. Res. 2000; 10: 1-5.
  56. Periquet I, Novak V, Sahenk Z, Freimer M, Nash S, Collins M, Nagaraja M, Mendell J: Painful sensory neuropathy: Prospective evaluation using skin biopsy. Neurology 1999; 53: 1641-47.
  57.  Mosek A, Novak V, Low PA: Autonomic nervous system changes in migraineurs. Headache 1999; 39: 108-17.
  58. Low PA, Novak V, Novak P, Spies JM, Petty GW: Cerebrovascular vasoregulation in postural tachycardia syndrome (POTS). Am. J. Med. Sci. 1999; 317:124-33.
  59. Novak V, Reeves AL, Novak P, Scarbrough F, Low PA: Autonomic changes during temporal lobe epilepsy seizures. J. Auton. Nerv. Syst. 1999; 77:195-02.
  60. Novak V, Novak P, Spies, JM, Opfer-Gehrking TL, Low PA: Hyperventilation contributes to cerebral hypoperfusion in orthostatic intolerance. Stroke 1998; 29: 1876-1881.
  61. Novak V, Novak P, Opfer-Gehrking TL, O’Brien P, Low PA: Predictors of orthostatic intolerance severity. Mayo Clinic Proc. 1998; 1141-1151.
  62. Novak V, Novak P, Spies, JM, Low PA: The autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 1998; 29: 104-11.
  63. 'Bharucha AE, Novak V, Camilleri M, Zinsmeister A., Hanson RB, Low PA: a2 modulation of colonic tone during hyperventilation. Am. J. Physiol. 1997; 273 (Gastrointest. Liver Physiol 36): G1135-G1140.
  64. Fujimura J, Camilleri M, Low PA, Novak V, Novak P, Opfer-Gehrking TL: Effect of perturbations and a meal on superior mesenteric artery flow in patients with orthostatic hypotension: Toward a test for abdominal sympathetic function. J. Auton. Nerv. Syst. 1997; 67: 15-23.
  65. Cupples WA, Novak P, Novak V, Salevsky F: Anesthetic specific alteration of renal blood flow dynamics in normotensive rats. Am. J. Physiol. 1996; 270 (Renal Fluid Electrolyte Physiol. 39) F82-F89.
  66. Novak V, Novak P, Opfer-Gehrking TL, Low PA: Postural tachycardia syndrome J. Auton. Nerv. Syst. 1996; 61:313-20.
  67. Novak V, Honos G, Schondorf R: Is the heart “empty” at syncope? J. Auton. Nerv. System 1996; 60:83-92.
  68. Novak V, Novak P, de Marchie M, Schondorf R: Desynchronization of cardiovascular rhythms after severe brainstem injury. Clin. Autonom. Res. 1995; 5: 24-30.
  69. Novak V, Novak P, Nadeau R, Kus T: Slow cardiovascular rhythms at tilt and syncope. J. Clin. Neurophys. 1995; 12: 64-71.
  70. Novak V, Novak P, Schondorf R: Accuracy of long duration noninvasive measurement of finger arterial pressure using Finapres: A spectral analysis approach. J. Clin. Monitoring 1994; 10: 118-26.
  71. Novak V, Novak P, deChamplain J, Nadeau R: Altered breathing pattern in hypertensive patients. Hypertension 1994; 23:104-13.
  72. Novak P, Novak V, Remillard G, Li Z: Slow brain activity and blood pressure instability in a patient with Alzheimer's disease. Clin. Autonom. Res. 1994; 4: 141-8.
  73. Novak P, Li Z, Novak V, Hatala R: Time-frequency mapping of the entire QRS complex in normal subjects and in post myocardial infarction patients. J. Electrocardiol.1994; 27: 49-60.
  74.  Novak P, Novak V: Time-frequency mapping of R-R intervals, blood pressure and respiratory signals. Med. Biol. Comp. Eng. 1993; 31:103-10.
  75.  Novak V, Novak P, de Champlain J, Le Blanc AR, Nadeau R: Influence of respiration on heart rate and blood pressure fluctuations. J. Appl. Phys. 1993; 74: 617-26.

 

Proceedings, Reviews, Chapters, and Editorials

  1. NICE guidelines Group and STARS Group: Transient loss of consciousness (TLoC) management in adults. National Clinical Guidelines Centre for Acute and Chronic Conditions. UK In press 2010.
  2. Lipsitz L, Novak V: Aging and the autonomic nervous system. In: Bannister R, Mathias C, editors. Autonomic Failure. Oxford University Press, In Press 2009.
  3. Novak V, Novak P. Diabetic neuropathy. In: Munshi M, Lipsitz L, editors. Informa Healthcare, New York. 2007,Chapter 16:,pp 207-221.
  4. Editorial: Rundek,T.Lali K: Visual input is critical for postural control in patients with chronic right hemispheric infarcts. Neurology 2010; 74:448-449.
  5. Novak V, Christiforidis G: Clinical promise. In: Robitaille PM, Berliner LJ, editors. Ultra high field magnetic resonance imaging (UHFMRI): Theory and applications, biological magnetic resonance. A series of contemporary topics and reviews. New York: Springer; Oct. 2006, vol.26, Chapter 13, pp 411- 437.
  6. Novak V, Lipsitz L: Aging and autonomic nervous system. In: Robertson D, Biaggioni I, Low PA, editors. Primer on the autonomic nervous system, 2nd ed. Boston: Elsevier Academic press; 2004, p. 191-193.
  7. Novak V: Autonomic Testing. In: Lynn DJ, Rae-Gray A, Newton H, editors. The 5-minute neurology consult. Philadelphia: Lippincott, Williams and Wilkins; 2004, p.40.
  8. Novak V: Orthostatic hypotension and orthostatic intolerance. In: Lynn DJ, Rae-Gray A, Newton H, editors. The 5-minute neurology consult. Philadelphia: Lippincott, Williams and Wilkins; 2004, p.326-7.
  9. Novak V, Mendell JRM: Evaluation of the peripheral neuropathy patient using autonomic reflex tests. In: Mendell JRM, Kissel JT, Cornblath DR, editors. Diagnosis and management of peripheral nerve disorders. Contemporary Neurology Series 59. Oxford: University Press; 2001, p.43-65.
  10. Low PA, Novak V, Novak P, Sandroni P, Schondorf R, Opfer-Gehrking TL: Postural tachycardia syndrome. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 681-97.
  11. Novak P, Novak V, Petty G, Low PA: Transcranial doppler evaluation in disorders of reduced orthostatic tolerance. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 349-68.
  12. Novak V, Saul JP, Eckberg D: Task force report on heart rate variability. Letter to the Editor. Circulation 1997; 96: 1056.
  13. Novak V, Novak P, Low PA: Time-frequency analysis of EEG and cardiovascular functions and their clinical applications. In: Low PA, editor. Clinical autonomic disorders. Philadelphia: Lippincott-Raven; 1997, p. 323-48.
  14. Novak V, Novak P, Reeves A, Low PA: Autonomic correlates of orthostatic intolerance and seizures. In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Methodology and clinical applications of blood pressure and heart rate analysis. Studies in health and technology; vol. 60. Amsterdam: IOS Press; 1999, p. 189-206.
  15. Novak V, Novak P, Low PA: Interpretation of oscillations in heart rate and blood pressure. In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Frontiers of blood pressure and heart rate analysis. Amsterdam: IOS Press; 1997 vol. 35, p. 129-42.
  16. Novak V, Novak P, Reeves A, Low PA: Autonomic correlates of orthostatic intolerance and seizures. In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Methodology and clinical applications of blood pressure and heart rate analysis. Studies in health and technology; vol. 60. Amsterdam: IOS Press; 1999, p. 189-206.
  17. Novak V, Novak P, Low PA: Interpretation of oscillations in heart rate and blood pressure.In: Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, editors. Frontiers of blood pressure and heart rate analysis. Amsterdam: IOS Press; 1997 vol. 35, p. 129-42.

Brad Manor, PhD 

Publications

  1. Manor B, Hao Y, Liu J, Zhang K, Chai Y, Lipsitz L, Peng CK, Novak V, Wang X, Zhang J, Fang J. Novel MRI-compatible tactile stimulator for cortical mapping of foot sole pressure stimuli with fMRI. Magnetic Resonance in Medicine 2012 (in press).
  2. Manor B, Newton E, Abduljalil A, Novak V. The relationship between brain volume and walking outcomes in older adults with and without diabetic peripheral neuropathy. Diabetes Care 2012 (in press).
  3. Manor B, Hu K, Peng CK, Lipsitz LA, Novak V. Posturo-respiratory synchronization: Effects of aging and stroke. Gait & Posture 2012 (in press).
  4. Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P. Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care 2011; 34: 2438-2441. PMCID: 3198286.
  5. Quach L, Galica AM, Jones RN, Procter-Gray E, Manor B, Hannon MT, Lipsitz LA. The nonlinear relationship between gait speed and falls: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study. Journal of the American Geriatrics Society 2011; 59: 1069-1073. PMCID: 3141220.
  6. Manor B, Costa MD, Hu K, Newton E, Starobinets O, Kang HG, Peng CK, Novak V, Lipsitz LA. Physiological complexity and system adaptability: Evidence from postural control dynamics of older adults. Journal of Applied Physiology 2010; 109: 1786-1791. PMCID: 3006415.
  7. Manor B, Hu K, Zhao P, Selim M, Alsop D, Novak P, Lipsitz LA, Novak V. Altered control of postural sway following cerebral infarction: a cross-sectional analysis. Neurology 2010; 74: 458-464. PMCID: 2830917.

 

Presentations

 

  1. Manor B, 2011. The Control of Balance in Aging and Disease: Insights from Advanced Brain Imaging and Signal Processing Techniques. Research Symposium, Peking University.
  2. Manor B, 2010. Altered Neural Control of Postural Sway Following Right-hemisphere Cerebral Infarction. Plenary Talk, International Stroke Conference, San Antonio.
  3. Manor B, 2009. Peripheral Neuropathy and the Sensitivity of the Sole: Functional Implications and Impact of Tai Chi. Mind-Body Research Seminar, Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School.
  4. Manor B, 2009. Walking Speed, Stability and Falls in Older Adults. Symposium, 56th Annual Meeting of the American College of Sports Medicine, Seattle, WA.